Strategies for developing novel therapeutics for sensorineural hearing loss.
Strategies for developing novel therapeutics for sensorineural hearing loss.
复制标题
开发感音神经性听力损失新疗法的策略。
DOI：
10.3389/fphar.2014.00206
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发表时间：
2014
影响因子：
5.6
通讯作者：
Nakagawa T
中科院分区：
文献类型：
--
作者：
Nakagawa T
感音神经性听力损失（SNHL）是世界上常见的残疾；然而，目前 SNHL 的药物治疗选择非常有限。先前涉及人类颞骨分析的研究表明，耳蜗退化是 SNHL 的常见机制。开发 SNHL 新型药物疗法的一个主要问题是哺乳动物耳蜗细胞的再生能力有限。然而，基础研究的最新进展已经产生了几种根据退化阶段诱导哺乳动物耳蜗再生的有效策略。此外，人类耳聋基因的鉴定及其在小鼠模型中的表征的最新进展阐明了 SNHL 的细胞和/或分子机制，这将有助于阐明治疗 SNHL 药物治疗的分子靶点。
Sensorineural hearing loss (SNHL) is a common disability in the world; however, at present, options for the pharmacological treatment of SNHL are very limited. Previous studies involving human temporal bone analyses have revealed that the degeneration of the cochlea is a common mechanism of SNHL. A major problem for the development of novel pharmacotherapy for SNHL has been the limited regeneration capacity in mammalian cochlear cells. However, recent progress in basic studies has led to several effective strategies for the induction of regeneration in the mammalian cochlea, in accordance with the stage of degeneration. In addition, recent advances in the identification of human deafness genes and their characterization in mouse models have elucidated cellular and/or molecular mechanisms of SNHL, which will contribute to clarify molecular targets of pharmacotherapy for treatment of SNHL.
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影响因子：
16.2
作者：
Mizutari K;Fujioka M;Hosoya M;Bramhall N;Okano HJ;Okano H;Edge AS
通讯作者：
Edge AS
影响因子：
64.8
作者：
Chen, Wei;Jongkamonwiwat, Nopporn;Abbas, Leila;Eshtan, Sarah Jacob;Johnson, Stuart L.;Kuhn, Stephanie;Milo, Marta;Thurlow, Johanna K.;Andrews, Peter W.;Marcotti, Walter;Moore, Harry D.;Rivolta, Marcelo N.
通讯作者：
Rivolta, Marcelo N.
DOI：
10.1016/j.ddmod.2012.02.001
发表时间：
2013
期刊：
Drug discovery today. Disease models
影响因子：
--
作者：
Esterberg, Robert;Coffin, Allison B;Ou, Henry;Simon, Julian A;Raible, David W;Rubel, Edwin W
通讯作者：
Rubel, Edwin W
影响因子：
3.7
作者：
Burns JC;Yoo JJ;Atala A;Jackson JD
通讯作者：
Jackson JD
影响因子：
4.6
作者：
Jan, Taha Adnan;Chai, Renjie;Cheng, Alan Gi-Lun
通讯作者：
Cheng, Alan Gi-Lun