The impact of ageing on lipid-mediated regulation of adult stem cell behavior and tissue homeostasis.
The impact of ageing on lipid-mediated regulation of adult stem cell behavior and tissue homeostasis.
复制标题
衰老对脂质介导的成年干细胞行为和组织稳态调节的影响。
DOI：
10.1016/j.mad.2020.111278
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发表时间：
2020-07
影响因子：
5.3
通讯作者：
Jones DL
中科院分区：
文献类型：
--
作者：
Sênos Demarco R;Clémot M;Jones DL
成体干细胞在整个生命过程中维持组织稳态，并提供能够响应压力和组织损伤进行组织修复的重要细胞库。与干细胞和/或容纳它们的专门小生境相关的变化已被证明会对干细胞的维持和活性产生负面影响。此外，代谢输入已成为控制干细胞行为的另一个关键层。在这里，我们将提出一个简短的回顾，脂质代谢如何影响成人干细胞的行为在稳态条件下，并推测如何在脂质代谢的变化可能会影响干细胞老化。这篇综述考虑了干细胞脂质代谢研究的未来，其长期目标是确定可以针对性地对抗或减缓与年龄相关的干细胞功能下降的机制。
Adult stem cells sustain tissue homeostasis throughout life and provide an important reservoir of cells capable of tissue repair in response to stress and tissue damage. Age-related changes to stem cells and/or the specialized niches that house them have been shown to negatively impact stem cell maintenance and activity. In addition, metabolic inputs have surfaced as another crucial layer in the control of stem cell behavior. Here, we will present a brief review of how lipid metabolism influences adult stem cell behavior under homeostatic conditions and speculate on how changes in lipid metabolism may impact stem cell aging. This review considers the future of lipid metabolism research in stem cells, with the long-term goal of identifying mechanisms that could be targeted to counter or slow the age-related decline in stem cell function.
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影响因子：
3.7
作者：
Adler BJ;Green DE;Pagnotti GM;Chan ME;Rubin CT
通讯作者：
Rubin CT
影响因子：
5.6
作者：
Ardah, Mustafa T.;Parween, Shama;Ansari, Suraiya A.
通讯作者：
Ansari, Suraiya A.
影响因子：
2.9
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Barrera G;Toaldo C;Pizzimenti S;Cerbone A;Pettazzoni P;Dianzani MU;Ferretti C
通讯作者：
Ferretti C
影响因子：
8.8
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Dainichi T;Hayden MS;Park SG;Oh H;Seeley JJ;Grinberg-Bleyer Y;Beck KM;Miyachi Y;Kabashima K;Hashimoto T;Ghosh S
通讯作者：
Ghosh S
影响因子：
64.5
作者：
Bailey AP;Koster G;Guillermier C;Hirst EM;MacRae JI;Lechene CP;Postle AD;Gould AP
通讯作者：
Gould AP