Epidemiology and individual, household and geographical risk factors of podoconiosis in Ethiopia: results from the first nationwide mapping.
Epidemiology and individual, household and geographical risk factors of podoconiosis in Ethiopia: results from the first nationwide mapping.
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DOI：
10.4269/ajtmh.14-0446
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Davey G
中科院分区：
文献类型：
--
作者：
Deribe K;Brooker SJ;Pullan RL;Sime H;Gebretsadik A;Assefa A;Kebede A;Hailu A;Rebollo MP;Shafi O;Bockarie MJ;Aseffa A;Reithinger R;Cano J;Enquselassie F;Newport MJ;Davey G
虽然足尘病是热带淋巴水肿的主要原因之一，是埃塞俄比亚的地方病，但其流行病学和危险因素知之甚少。收集了来自659个县（区）1 315个社区的129 959名个人的个人水平数据，用于全国范围内的淋巴丝虫病和尘肺病综合调查。使用免疫层析卡检测血液样本的循环班氏丝虫抗原。通过排除下肢淋巴水肿的其他潜在原因，使用临床算法诊断为足尘病。使用贝叶斯多水平模型来识别个人和环境风险因素。总体而言，129，959名（6.2%，95%置信区间[CI] 6.1-6.4%）受调查个体中有8，110名被确定患有下肢淋巴水肿，其中5，253名（4.0%，95% CI 3.9-4.1%）被确认为足尘病病例。在多变量分析中，女性、老年人、未婚、洗脚频率低于每日、半熟练或失业与足尘病风险增加显著相关。接受正规教育和居住在有盖地板的房子里与患足尘病的风险降低有关。在埃塞俄比亚各地，足尘病具有明显的地理差异，风险的变化与降雨量、植被指数和海拔高度的变化有关。
Although podoconiosis is one of the major causes of tropical lymphoedema and is endemic in Ethiopia its epidemiology and risk factors are poorly understood. Individual-level data for 129,959 individuals from 1,315 communities in 659 woreda (districts) were collected for a nationwide integrated survey of lymphatic filariasis and podoconiosis. Blood samples were tested for circulating Wuchereria bancrofti antigen using immunochromatographic card tests. A clinical algorithm was used to reach a diagnosis of podoconiosis by excluding other potential causes of lymphoedema of the lower limb. Bayesian multilevel models were used to identify individual and environmental risk factors. Overall, 8,110 of 129,959 (6.2%, 95% confidence interval [CI] 6.1–6.4%) surveyed individuals were identified with lymphoedema of the lower limb, of whom 5,253 (4.0%, 95% CI 3.9–4.1%) were confirmed to be podoconiosis cases. In multivariable analysis, being female, older, unmarried, washing the feet less frequently than daily, and being semiskilled or unemployed were significantly associated with increased risk of podoconiosis. Attending formal education and living in a house with a covered floor were associated with decreased risk of podoconiosis. Podoconiosis exhibits marked geographical variation across Ethiopia, with variation in risk associated with variation in rainfall, enhanced vegetation index, and altitude.
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影响因子：
12.3
作者：
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通讯作者：
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