Application of independent component analysis to microarrays.
Application of independent component analysis to microarrays.
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DOI:
10.1186/gb-2003-4-11-r76
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发表时间:
2003
期刊:
影响因子:
12.3
通讯作者:
Batzoglou S
中科院分区:
文献类型:
--
作者:
Lee SI;Batzoglou S
Linear and nonlinear independent component analysis (ICA) was used to project microarray data into statistically independent components that correspond to putative biological processes, and to cluster genes according to over- or under-expression in each component. We apply linear and nonlinear independent component analysis (ICA) to project microarray data into statistically independent components that correspond to putative biological processes, and to cluster genes according to over- or under-expression in each component. We test the statistical significance of enrichment of gene annotations within clusters. ICA outperforms other leading methods, such as principal component analysis, k-means clustering and the Plaid model, in constructing functionally coherent clusters on microarray datasets from Saccharomyces cerevisiae, Caenorhabditis elegans and human.
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DOI:
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