Increased striatal glutamate transporter by repeated intermittent administration of methamphetamine
Increased striatal glutamate transporter by repeated intermittent administration of methamphetamine
复制标题
通过重复间歇性服用甲基苯丙胺增加纹状体谷氨酸转运蛋白
DOI：
10.1111/j.1440-1819.1996.tb01682.x
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发表时间：
1996
影响因子：
11.9
通讯作者：
H. Nakai
中科院分区：
文献类型：
--
作者：
Y. Shirai;O. Shirakawa;N. Nishino;Naoaki Saito;H. Nakai
我们研究了在单次或多次间歇性给药甲基苯丙胺（MAP）处理的大鼠脑中谷氨酸（Glu）转运体GLT‐1的免疫反应性。在反复间歇性MAP治疗诱导的行为致敏率中，GLT‐1免疫反应性增加51%。在所有区域GLT - 1免疫反应性在单次给药MAP的大鼠和对照大鼠之间没有差异。这些结果表明纹状体的高谷氨酸能活性参与了MAP引起的行为致敏的诱导。
Abstract We have examined the immunoreactivities of a glutamate (Glu) transporter, GLT‐1, in rat brains treated with a single or repeated intermittent administration of methamphetamine (MAP). In the stratum of behaviorally sensitized rate induced by repeated intermittent MAP treatment, GLT‐1 immunoreactivities were increased by 51%. There was no difference in the GLT‐1 immunoreactivities in all regions examined between rate treated with a single administration of MAP and the control rats. These results suggest that hyperglutamatergic activity in the striatum is involved in the induction of behavioral sensitization caused by MAP.
DOI：
--
发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
M. Wolf;F. J. White;R. Nassar;R. J. Brooderson;M. Khansa
通讯作者：
M. Wolf;F. J. White;R. Nassar;R. J. Brooderson;M. Khansa
谷氨酰胺合成酶抑制后的神经胶质和神经元谷氨酸转运。
影响因子：
5.8
作者：
Rothstein,JD;Tabakoff,B
通讯作者：
Tabakoff,B