Dosimetric comparison of MR-linac-based IMRT and conventional VMAT treatment plans for prostate cancer.
Dosimetric comparison of MR-linac-based IMRT and conventional VMAT treatment plans for prostate cancer.
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DOI：
10.1186/s13014-021-01858-7
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发表时间：
2021-07-21
期刊：
影响因子：
--
通讯作者：
Belka C
中科院分区：
文献类型：
--
作者：
Da Silva Mendes V;Nierer L;Li M;Corradini S;Reiner M;Kamp F;Niyazi M;Kurz C;Landry G;Belka C
本研究的目的是评价和比较计划用于低场强磁共振（MR）引导直线加速器（linac）输送的调强放射治疗（IMRT）计划（标记为IMRT MRL计划）和临床常规体积调弧治疗（VMAT）计划治疗前列腺癌（PCa）的性能。两个计划均使用原始计划靶体积（PTV）裕度。此外，通过使用较小的PTV裕度创建IMRT MRL计划，估计了MR引导的潜在剂量学益处。考虑了20例既往接受过常规VMAT治疗的PCa患者。对于每个患者，使用低场MR直线加速器治疗计划系统创建两个不同的IMRT MRL计划：一个具有原始（orig.）PTV利润率和其他减少（红色。）PTV边缘。比较了与靶区覆盖率相关的剂量指数以及靶区和危及器官（OAR）的剂量体积直方图（DVH）参数。此外，还评价了每个计划的估计治疗输送时间和监测单元（MU）数量。对于所有三种类型的治疗计划，高剂量区的剂量分布和靶体积DVH参数（D98%、D50%、D2%和V95%）相似，大多数情况下偏差小于1%。两个IMRT MRL计划（原始和红色。PTV边缘）显示相似的均匀性指数（HI），但与VMAT相比，一致性指数（CI）值也更差。IMRT MRL计划显示，当使用原始PTV边界时，OAR保留相似，但当红色时，保留明显更好。应用PTV边界。两种IMRT MRL计划的MU数量更高，预测治疗输送时间更长。当应用相同的PTV裕度时，VMAT和IMRT MRL计划之间的计划质量相当。然而，在线MR引导的自适应放疗允许PTV边缘的减少。带红色的。PTV边缘，可以实现更好地保留周围组织，同时保持足够的靶覆盖。尽管如此，较长的治疗输送时间，特点的调强放射治疗技术，必须预期。
The aim of this study was to evaluate and compare the performance of intensity modulated radiation therapy (IMRT) plans, planned for low-field strength magnetic resonance (MR) guided linear accelerator (linac) delivery (labelled IMRT MRL plans), and clinical conventional volumetric modulated arc therapy (VMAT) plans, for the treatment of prostate cancer (PCa). Both plans used the original planning target volume (PTV) margins. Additionally, the potential dosimetric benefits of MR-guidance were estimated, by creating IMRT MRL plans using smaller PTV margins. 20 PCa patients previously treated with conventional VMAT were considered. For each patient, two different IMRT MRL plans using the low-field MR-linac treatment planning system were created: one with original (orig.) PTV margins and the other with reduced (red.) PTV margins. Dose indices related to target coverage, as well as dose-volume histogram (DVH) parameters for the target and organs at risk (OAR) were compared. Additionally, the estimated treatment delivery times and the number of monitor units (MU) of each plan were evaluated. The dose distribution in the high dose region and the target volume DVH parameters (D98%, D50%, D2% and V95%) were similar for all three types of treatment plans, with deviations below 1% in most cases. Both IMRT MRL plans (orig. and red. PTV margins) showed similar homogeneity indices (HI), however worse values for the conformity index (CI) were also found when compared to VMAT. The IMRT MRL plans showed similar OAR sparing when the orig. PTV margins were used but a significantly better sparing was feasible when red. PTV margins were applied. Higher number of MU and longer predicted treatment delivery times were seen for both IMRT MRL plans. A comparable plan quality between VMAT and IMRT MRL plans was achieved, when applying the same PTV margin. However, online MR-guided adaptive radiotherapy allows for a reduction of PTV margins. With a red. PTV margin, better sparing of the surrounding tissues can be achieved, while maintaining adequate target coverage. Nonetheless, longer treatment delivery times, characteristic for the IMRT technique, have to be expected.
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影响因子：
2.6
作者：
Maund, I. F.;Benson, R. J.;Poynter, A.
通讯作者：
Poynter, A.
影响因子：
2.6
作者：
Khoo, V. S.;Joon, D. L.
通讯作者：
Joon, D. L.
影响因子：
3.7
作者：
Choi, Chang Heon;Kim, Jin Ho;Park, Jong Min
通讯作者：
Park, Jong Min
DOI：
10.7759/cureus.2422
发表时间：
2018-04-04
期刊：
Cureus
影响因子：
--
作者：
Mittauer K;Paliwal B;Hill P;Bayouth JE;Geurts MW;Baschnagel AM;Bradley KA;Harari PM;Rosenberg S;Brower JV;Wojcieszynski AP;Hullett C;Bayliss RA;Labby ZE;Bassetti MF
通讯作者：
Bassetti MF
DOI：
10.1016/j.ijrobp.2009.03.078
发表时间：
2010-03-01
影响因子：
7
作者：
Michalski, Jeff M.;Gay, Hiram;Jackson, Andrew;Tucker, Susan L.;Deasy, Joseph O.
通讯作者：
Deasy, Joseph O.