Optical fiber LSPR biosensor prepared by gold nanoparticle assembly on polyelectrolyte multilayer.

Optical fiber LSPR biosensor prepared by gold nanoparticle assembly on polyelectrolyte multilayer.
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聚电解质多层膜上金纳米颗粒组装制备光纤LSPR生物传感器

DOI:
10.3390/s100403585
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发表时间:
2010
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Xu W
Xu W
中科院分区:
其他
文献类型:
--
作者:
Shao Y;Xu S;Zheng X;Wang Y;Xu W

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本文提供了一种构建光纤局域表面等离子体共振(LSPR)生物传感器的新方法。在无包层光纤的聚电解质(PE)多层改性侧壁上构建了金纳米颗粒(NP)组装膜作为传感层。通过采用三层PE结构,我们获得了单分散金纳米粒子组装薄膜。该LSPR传感器的制备过程简单且节省时间。光纤LSPR传感器具有更高的灵敏度和出色的再现性。对抗体响应的较高抗干扰能力使其成为便携式免疫传感器应用的有前景的方法。
This article provides a novel method of constructing an optical fiber localized surface plasmon resonance (LSPR) biosensor. A gold nanoparticle (NP) assembled film as the sensing layer was built on the polyelectrolyte (PE) multilayer modified sidewall of an unclad optical fiber. By using a trilayer PE structure, we obtained a monodisperse gold NP assembled film. The preparation procedure for this LSPR sensor is simple and time saving. The optical fiber LSPR sensor has higher sensitivity and outstanding reproducibility. The higher anti-interference ability for response to an antibody makes it a promising method in application as a portable immuno-sensor.
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