Tracheal reconstruction with a free vascularized myofascial flap: preclinical investigation in a porcine model to human clinical application.
Tracheal reconstruction with a free vascularized myofascial flap: preclinical investigation in a porcine model to human clinical application.
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带有自由血管化肌筋膜皮瓣的气管重建：在人类临床应用的猪模型中进行临床前研究。
DOI：
10.1038/s41598-017-10733-z
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发表时间：
2017-08-30
影响因子：
4.6
通讯作者：
Choi EC
中科院分区：
文献类型：
--
作者：
Kim WS;Chang JW;Jang WS;Seo YJ;Kang ML;Sung HJ;Kim DH;Kim JM;Park JH;Ban MJ;Na G;Shin SH;Byeon HK;Koh YW;Kim SH;Baik HK;Choi EC
尽管有各种气管重建的方法，例如用纤维束简单缝合和用邻近的软组织或肌肉覆盖，但> 50%气管长度的大缺损仍然存在临床挑战。组织工程，最近有希望的方式，可能解决这个问题，需要一个长期的准备期干细胞接种在支架上和相对侵入性的干细胞收获程序。作为一种替代方法，我们使用带血管蒂的肌筋膜瓣进行气管重建。在4个猪模型中，2个模型使用了腹壁深下动脉穿支（DIEP），2个模型使用了腹壁上级动脉穿支（SEAP）。分析移植肌筋膜瓣表面在气道环境中的变化。DIEP组皮瓣因静脉充血而失败。术后12周，SEAP组均未出现任何呼吸窘迫体征;植入物内表面为复层鳞状上皮，纤毛稀疏。在临床环境中，一名患者接受了带血管肌筋膜瓣气管重建术，随访2年，健康状况良好，无呼吸窘迫症状。
Although there are various methods for tracheal reconstruction, such as a simple approximation with suturing and coverage with adjacent soft tissue or muscle, large defects >50% of the tracheal length still present a clinical challenge. Tissue engineering, a recent promising way to possibly resolve this problem, requires a long preparatory period for stem cell seeding on a scaffold and relatively invasive procedures for stem cell harvesting. As an alternative, we used a vascularized myofascial flap for tracheal reconstruction. In four porcine models, the deep inferior epigastric perforator (DIEP) was used in two and the superior epigastric artery perforator (SEAP) in two. Transformation of the surface of the transplanted myofascial flap was analyzed in the airway environment. The flaps failed in the DIEP group due to venous congestion. At 12 weeks postoperatively, none of SEAP group showed any signs of respiratory distress; the inner surface of the implant exhibited stratified squamous epithelium with sparse cilia. In the clinical setting, a patient who underwent a tracheal reconstruction with a vascularized myofascial flap and 2-year follow-up was in good health with no respiratory distress symptoms.
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DOI：
10.1097/gox.0000000000000097
发表时间：
2014-07
期刊：
Plastic and reconstructive surgery. Global open
影响因子：
--
作者：
Haykal S;Salna M;Waddell TK;Hofer SO
通讯作者：
Hofer SO
DOI：
10.1016/j.bjps.2015.06.006
发表时间：
2015-10-01
影响因子：
2.7
作者：
Bodin, Frederic;Diana, Michele;Bruant-Rodier, Catherine
通讯作者：
Bruant-Rodier, Catherine
影响因子：
168.9
作者：
Macchiarini, Paolo;Jungebluth, Philipp;Birchall, Martin A.
通讯作者：
Birchall, Martin A.
影响因子：
2.6
作者：
Delaere, P;Hierner, R;Hermans, R
通讯作者：
Hermans, R
影响因子：
4.9
作者：
Hong, Hyun Jun;Chang, Jae Won;Choi, Eun Chang
通讯作者：
Choi, Eun Chang