An Updated Perspective on the Dual-Track Model of Enterocyte Fat Metabolism.
An Updated Perspective on the Dual-Track Model of Enterocyte Fat Metabolism.
复制标题
DOI：
10.1016/j.jlr.2022.100278
复制
发表时间：
2022-11
影响因子：
6.5
通讯作者：
Haeusler, Rebecca A.
中科院分区：
文献类型：
--
作者：
Cook, Joshua R.;Kohan, Alison B.;Haeusler, Rebecca A.
关键词：
小肠上皮细胞通常被认为是营养吸收的管道，但人们越来越重视肠上皮细胞在脂质代谢中的更大和更动态的作用。在我们对这种生理学的知识中仍然存在相当大的差距，但似乎肠上皮细胞的结构极化决定了其在脂肪分配中的行为，根据其在顶膜和基底膜上的吸收来不同地处理脂肪。在这篇综述中，我们综合了现有的数据和思考，通过人体综合生理学的透镜，这种双轨模型的肠细胞脂肪代谢。顶端轨道包括通过顶端刷状缘膜的膳食脂质吸收的典型途径，导致这些脂质包装和分泌为乳糜微粒。然而，这条轨道也保留了一部分细胞质脂滴内的膳食脂质供以后使用，包括“第二餐效应”，这仍然知之甚少。同时，肠上皮细胞通过受体介导的富含脂蛋白或其残余物的输入、游离脂肪酸的局部水解和内化或使用基底外侧吸收的底物的肠上皮细胞从头脂肪生成的机制，跨越基底外侧膜吸收循环脂肪。基底外侧轨道脂肪的最终目的地可能包括脂肪酸氧化、结构脂质合成、储存在细胞质脂滴中或最终切除，尽管该基底外侧轨道的调节和目的仍然是神秘的。我们建议肠上皮细胞整合脂质通量沿着这两个轨道，以校准其整体程序的脂质代谢。
The small intestinal epithelium has classically been envisioned as a conduit for nutrient absorption, but appreciation is growing for a larger and more dynamic role for enterocytes in lipid metabolism. Considerable gaps remain in our knowledge of this physiology, but it appears that the enterocyte’s structural polarization dictates its behavior in fat partitioning, treating fat differently based on its absorption across the apical versus the basolateral membrane. In this review, we synthesize existing data and thought on this dual-track model of enterocyte fat metabolism through the lens of human integrative physiology. The apical track includes the canonical pathway of dietary lipid absorption across the apical brush-border membrane, leading to packaging and secretion of those lipids as chylomicrons. However, this track also reserves a portion of dietary lipid within cytoplasmic lipid droplets for later uses, including the “second-meal effect,” which remains poorly understood. At the same time, the enterocyte takes up circulating fats across the basolateral membrane by mechanisms that may include receptor-mediated import of triglyceride-rich lipoproteins or their remnants, local hydrolysis and internalization of free fatty acids, or enterocyte de novo lipogenesis using basolaterally absorbed substrates. The ultimate destinations of basolateral-track fat may include fatty acid oxidation, structural lipid synthesis, storage in cytoplasmic lipid droplets, or ultimate resecretion, although the regulation and purposes of this basolateral track remain mysterious. We propose that the enterocyte integrates lipid flux along both of these tracks in order to calibrate its overall program of lipid metabolism.
登录
查看更多内容
影响因子：
3
作者：
Covasa, M;Ritter, RC
通讯作者：
Ritter, RC
影响因子：
9.8
作者：
COHN, JS;MCNAMARA, JR;SCHAEFER, EJ
通讯作者：
SCHAEFER, EJ
DOI：
10.1161/01.atv.0000172689.53992.25
发表时间：
2005-08-01
影响因子：
8.7
作者：
Adiels, M;Borén, J;Taskinen, MR
通讯作者：
Taskinen, MR
影响因子：
11.1
作者：
Bjornson, E.;Packard, C. J.;Boren, J.
通讯作者：
Boren, J.
影响因子：
8.8
作者：
Aguilar, Esther;Esteves, Pauline;Alves-Guerra, Marie-Clotilde
通讯作者：
Alves-Guerra, Marie-Clotilde