Temporal variation in the association between benzene and leukemia mortality.
Temporal variation in the association between benzene and leukemia mortality.
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DOI：
10.1289/ehp.10841
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发表时间：
2008-03
影响因子：
10.4
通讯作者：
Richardson DB
中科院分区：
文献类型：
--
作者：
Richardson DB
苯是一种人类致癌物质。接触苯发生在职业和环境设置。我评估了苯相关性白血病随接触时年龄和接触后时间的变化。我评估了来自1,845名橡胶盐酸盐工人的数据。苯中毒-白血病死亡率趋势采用比例风险回归法进行估计。苯对白血病发病率影响的时间变化通过暴露时间窗和多阶段癌症模型拟合进行评估。白血病死亡率与苯暴露之间的关联在暴露后10年内最大[10 ppm-年的相对比率（RR）= 1.19; 95%置信区间（CI），1.10-1.29];在暴露后10至< 20年期间，关联程度较小（10 ppm-年的RR = 1.05; 95% CI，0.97-1.13）;暴露后≥ 20年无相关证据。白血病与≥ 45岁时累积的苯暴露（10 ppm-年的RR = 1.11; 95% CI，1.04-1.17）的相关性比与较年轻时累积的苯暴露（10 ppm-年的RR = 1.01; 95% CI，0.92-1.09）的相关性更强。联合，这些时间效应可以有效地模拟为一个多阶段的过程中，苯暴露影响疾病诱导的倒数第二个阶段。应进一步重视评估老年工人对苯诱发白血病的易感性。
Benzene is a human carcinogen. Exposure to benzene occurs in occupational and environmental settings. I evaluated variation in benzene-related leukemia with age at exposure and time since exposure. I evaluated data from a cohort of 1,845 rubber hydrochloride workers. Benzene exposure–leukemia mortality trends were estimated by applying proportional hazards regression methods. Temporal variation in the impact of benzene on leukemia rates was assessed via exposure time windows and fitting of a multistage cancer model. The association between leukemia mortality and benzene exposures was of greatest magnitude in the 10 years immediately after exposure [relative rate (RR) at 10 ppm-years = 1.19; 95% confidence interval (CI), 1.10–1.29]; the association was of smaller magnitude in the period 10 to < 20 years after exposure (RR at 10 ppm-years = 1.05; 95% CI, 0.97–1.13); and there was no evidence of association ≥ 20 years after exposure. Leukemia was more strongly associated with benzene exposures accrued at ≥ 45 years of age (RR at 10 ppm-years = 1.11; 95% CI, 1.04–1.17) than with exposures accrued at younger ages (RR at 10 ppm-years = 1.01; 95% CI, 0.92–1.09). Jointly, these temporal effects can be efficiently modeled as a multistage process in which benzene exposure affects the penultimate stage in disease induction. Further attention should be given to evaluating the susceptibility of older workers to benzene-induced leukemia.
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影响因子：
158.5
作者：
RINSKY, RA;SMITH, AB;LANDRIGAN, PJ
通讯作者：
LANDRIGAN, PJ
影响因子：
10.4
作者：
HRICKO, A
通讯作者：
HRICKO, A
影响因子：
3.5
作者：
Silver, SR;Rinsky, RA;Lai, D
通讯作者：
Lai, D
DOI：
10.1080/00039896.1990.9935932
发表时间：
1990-03-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
CHECKOWAY, H;PEARCE, N;DEMENT, JM
通讯作者：
DEMENT, JM
影响因子：
3.5
作者：
AXELSON, O;STEENLAND, K
通讯作者：
STEENLAND, K