New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption.
New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption.
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心脏生理适应中能量底物利用和代谢重塑的新认识
DOI：
10.3389/fphys.2022.831829
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发表时间：
2022
影响因子：
4
通讯作者：
Qiu H
中科院分区：
文献类型：
--
作者：
Shi X;Qiu H
心功能高度依赖于充足的能量供应。心肌能量代谢紊乱在心脏发病中起着重要作用。越来越多的证据表明，心脏代谢的改变也是心脏对各种生理条件的适应性反应的重要组成部分，以满足特定的能量需求。本文综述了一些关于心肌能量底物代谢的新研究，以及在运动和心脏发育等生理条件下心脏代谢重塑及其相关机制的最新发现。研究心脏在这些条件下的基本代谢特征有助于理解心脏在生理适应过程中代谢调节的意义，并进一步了解与心脏发病机制相关的不适应代谢变化，从而为探索心脏疾病的新治疗策略开辟新的途径。
Cardiac function highly relies on sufficient energy supply. Perturbations in myocardial energy metabolism play a causative role in cardiac pathogenesis. Accumulating evidence has suggested that modifications of cardiac metabolism are also an essential part of the adaptive responses to various physiological conditions in the heart to meet specific energy needs. The review highlighted some new studies on basic myocardial energy substrate metabolism and updated recent findings regarding cardiac metabolic remodeling and their associated mechanisms under physiological conditions, including exercise and cardiac development. Studying basic metabolic profiles in the heart in these conditions can contribute to understanding the significance of metabolic regulation in the heart during physiological adaption and gaining further insights into the maladaptive metabolic changes associated with cardiac pathogenesis, thus opening up new avenues to exploring novel therapeutic strategies in cardiac diseases.
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影响因子：
20.1
作者：
Hu D;Linders A;Yamak A;Correia C;Kijlstra JD;Garakani A;Xiao L;Milan DJ;van der Meer P;Serra M;Alves PM;Domian IJ
通讯作者：
Domian IJ
影响因子：
9.8
作者：
Breckenridge RA;Piotrowska I;Ng KE;Ragan TJ;West JA;Kotecha S;Towers N;Bennett M;Kienesberger PC;Smolenski RT;Siddall HK;Offer JL;Mocanu MM;Yelon DM;Dyck JR;Griffin JL;Abramov AY;Gould AP;Mohun TJ
通讯作者：
Mohun TJ
影响因子：
5.2
作者：
Cerychova R;Pavlinkova G
通讯作者：
Pavlinkova G
影响因子：
15.9
作者：
GERTZ, EW;WISNESKI, JA;NEESE, RA
通讯作者：
NEESE, RA
影响因子：
8
作者：
Bezzerides, Vassilios J.;Platt, Colin;Rosenzweig, Anthony
通讯作者：
Rosenzweig, Anthony