Ontogenic expression pattern and genetic polymorphisms of the fatty acid transport protein 4 (FATP4) gene in Chinese chicken populations.
Ontogenic expression pattern and genetic polymorphisms of the fatty acid transport protein 4 (FATP4) gene in Chinese chicken populations.
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DOI：
10.3390/ijms13066820
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发表时间：
2012
影响因子：
5.6
通讯作者：
Liu YP
中科院分区：
文献类型：
--
作者：
Wang Y;Zhu Q;Yang L;Liu YP
本研究对二郎山鸡FATP 4基因的多态性进行了分析。通过对鸡样本进行FATP 4基因测序分析，共鉴定出9种遗传变异。在S 01和S 05群体中，第6外显子的g.5608778C>T和g.5608814G>A两个SNPs分别与某些胴体性状（如活重、胴体重、净膛重）显著相关（p < 0.05）。在S 05群体中，单倍型3（T-G）和单倍型2（C-A）分别与活重、胴体重、全净膛重和半净膛重等部分胴体性状的较高和较低相关。此外，我们还研究了该基因在山地乌骨鸡个体发育过程中的表达谱。实时荧光定量PCR分析表明，FATP 4 mRNA在小肠组织中的表达水平最高。FATP 4 mRNA在各组织中的表达随年龄的增长呈现出明显的发育变化。这些结果表明，FATP 4基因可能在控制鸡胴体性状中起重要作用。
In the current research, the polymorphism of FATP4 gene was analyzed in Erlang Mountainous chickens. A total of nine genetic variants were identified by FATP4 gene sequencing analysis across the chicken samples. Significant associations (p < 0.05) were observed for two SNPs (g.5608778C>T and g.5608814G>A in exon 6) with certain carcass traits (such as live weight, carcass weight, eviscerated weight) in S01 and S05 populations, respectively. Meanwhile, in S05 population, haplotype 3 (T-G) and haplotype 2 (C-A) were associated with higher and lower partial carcass traits such as live weight, carcass weight, eviscerated weight and semi-eviscerated weight, respectively. Moreover, we investigated the expression profile of this gene during ontogenesis in Mountainous black-boned chicken. Quantitative real-time PCR analysis showed that FATP4 mRNA had the highest expression level in small intestine tissue over all other tissues examined. The FATP4 mRNA levels presented remarkable developmental changes with age in the various tissues. These results suggested that the FATP4 gene might play an important role in controlling chicken carcass traits.
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DOI：
10.1083/jcb.200207080
发表时间：
2003-06-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Herrmann T;van der Hoeven F;Grone HJ;Stewart AF;Langbein L;Kaiser I;Liebisch G;Gosch I;Buchkremer F;Drobnik W;Schmitz G;Stremmel W
通讯作者：
Stremmel W
DOI：
10.1152/ajpendo.00194.2005
发表时间：
2006-01-01
影响因子：
5.1
作者：
Bower, JF;Davis, JM;Barakat, HA
通讯作者：
Barakat, HA
影响因子：
6.5
作者：
Schmuth, M;Ortegon, AM;Stahl, A
通讯作者：
Stahl, A
影响因子：
30.8
作者：
Daly, MJ;Rioux, JD;Lander, ES
通讯作者：
Lander, ES
影响因子：
4.8
作者：
Huang, H;Starodub, O;Schroeder, F
通讯作者：
Schroeder, F