LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases.
LncRNA MEG3: Potential stock for precision treatment of cardiovascular diseases.
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DOI：
10.3389/fphar.2022.1045501
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
心血管疾病的患病率和死亡率正在上升，迫切需要新的治疗策略。从基本发病机制来看，心血管疾病的发生发展与心肌细胞、内皮细胞等相关细胞的炎症、凋亡、纤维化和自噬有关。母亲表达基因3（MEG 3）参与人类疾病过程的报道越来越多。P53和PI 3 K/Akt是MEG 3参与调控细胞凋亡的重要途径。MEG 3直接或竞争性地与miRNA结合，参与细胞凋亡、炎症、氧化应激、内质网应激、EMT等过程。LncRNA MEG 3主要参与恶性肿瘤、代谢性疾病、免疫系统疾病、心脑血管疾病等，LncRNA MEG 3在心肌细胞、成纤维细胞和内皮细胞中具有多种病理作用，在预防和治疗AS、MIRI、高血压和HF等方面具有巨大的临床应用潜力。本文将从MEG 3的作用机制、其他全身性疾病和心血管疾病等方面综述其研究进展，并指出其在心血管疾病防治中的巨大潜力。lncRNA也在内皮细胞中发挥作用。此外，lncRNA MEG 3在肿瘤疾病中显示出生物标志物价值、预后价值和治疗反应测量。我们大胆推测，MEG 3将在肿瘤心脏病的新兴学科中发挥作用。
The prevalence and mortality rates of cardiovascular diseases are increasing, and new treatment strategies are urgently needed. From the perspective of basic pathogenesis, the occurrence and development of cardiovascular diseases are related to inflammation, apoptosis, fibrosis and autophagy of cardiomyocytes, endothelial cells and other related cells. The involvement of maternally expressed gene 3 (MEG3) in human disease processes has been increasingly reported. P53 and PI3K/Akt are important pathways by which MEG3 participates in regulating cell apoptosis. MEG3 directly or competitively binds with miRNA to participate in apoptosis, inflammation, oxidative stress, endoplasmic reticulum stress, EMT and other processes. LncRNA MEG3 is mainly involved in malignant tumors, metabolic diseases, immune system diseases, cardiovascular and cerebrovascular diseases, etc., LncRNA MEG3 has a variety of pathological effects in cardiomyocytes, fibroblasts and endothelial cells and has great clinical application potential in the prevention and treatment of AS, MIRI, hypertension and HF. This paper will review the research progress of MEG3 in the aspects of mechanism of action, other systemic diseases and cardiovascular diseases, and point out its great potential in the prevention and treatment of cardiovascular diseases. lncRNAs also play a role in endothelial cells. In addition, lncRNA MEG3 has shown biomarker value, prognostic value and therapeutic response measurement in tumor diseases. We boldly speculate that MEG3 will play a role in the emerging discipline of tumor heart disease.
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