Distribution of intraepithelial lymphocytes, mast cells, and goblet cells in the intestine of alpaca
Distribution of intraepithelial lymphocytes, mast cells, and goblet cells in the intestine of alpaca
复制标题
羊驼肠道上皮内淋巴细胞、肥大细胞和杯状细胞的分布
DOI：
10.1111/ahe.12823
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Jing Cao
中科院分区：
文献类型：
--
作者：
Meng Ma;Xue Bai;Zixu Wang;Yulan Dong;Yaoxing Chen;Jing Cao
反刍动物肠道疾病多发，易受外源性物质侵袭，而肠粘膜屏障是机体免疫防御的第一道防线。目前对羊驼肠黏膜免疫屏障结构的研究还不完全。因此，本研究采用组织学、组织化学和免疫组织化学方法，对羊驼肠道黏膜屏障结构和免疫相关细胞的分布特征进行了研究。结果表明，羊驼肠道由粘膜层、粘膜下层、肌层和浆膜层组成。上皮内淋巴细胞分布于大肠粘膜上皮和腺体。肥大细胞分布于肠各段，主要分布于肠固有层、肠腺、十二指肠腺周围以及肌层内，胞质颗粒明显。酸性杯状细胞主要分布于回肠粘膜上皮和回肠肠腺，唾液酸粘蛋白主要表达于结肠。羊驼肠黏膜中与免疫系统相关的细胞在抵御外来微生物入侵和感染中起着重要的保护作用，这一结果为揭示羊驼胃肠道疾病的发生提供了理论依据。
Intestinal diseases in ruminants are frequent and susceptible to invasion by exogenous substances, and the intestinal mucosal barrier is the first line of defence of the body's immune defence. At present, the study on the structure of intestinal mucosal immune barrier in alpaca is incomplete. Therefore, the alpaca intestines were studied to show the distribution characteristics of intestinal mucosal barrier structure and cells associated with immune system using histology, histochemistry, and immunohistochemistry. The results showed that the intestinal tract of alpaca was composed of mucosa, submucosa, muscularis, and serosa. Intraepithelial lymphocytes were distributed in mucosal epithelium and glands of the large intestine. Mast cells were distributed in each segment of the intestine, mainly in the intestinal lamina propria, intestinal glands, and duodenal glands around, as well as in the muscularis, and the particles of cytoplasm were obvious. Acidic goblet cells were mainly distributed in the ileal mucosal epithelium and ileal intestinal glands, while sialomucins were mainly expressed in the colon. The cells associated with the immune system in the intestinal mucosa of alpaca play an important role in protecting against foreign microbial invasion and infection, and this result provides a theoretical basis for revealing the occurrence of gastrointestinal diseases in alpaca.
影响因子：
6.8
作者：
Etzold, Sabrina;Juge, Nathalie
通讯作者：
Juge, Nathalie