Obesity during pregnancy and fetal iron status: is Hepcidin the link?
Obesity during pregnancy and fetal iron status: is Hepcidin the link?
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DOI：
10.1038/jp.2012.81
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发表时间：
2013-03
影响因子：
2.9
通讯作者：
Meydani, S. N.
中科院分区：
文献类型：
--
作者：
Dao, M. C.;Sen, S.;Iyer, C.;Klebenov, D.;Meydani, S. N.
目的：探讨肥胖相关炎症对母体和胎儿铁状态的影响。我们假设肥胖孕妇会有更高的炎症和海普西丁水平，与瘦身对照相比，她们的婴儿铁状态会受损。15名肥胖(Ob)和15名瘦身(LC)妇女在怀孕中期被招募。检测母血和脐带血中铁状态、炎症和海普西丁的标记物。采用t检验比较肥胖组和瘦肉组，并测定母血和脐带血之间的皮尔逊相关系数。肥胖组母体C反应蛋白(P<；0.01)和海普西丁(P<；0.01)较高，脐血铁(P<；0.01)较低。母血BMI(p<；0.01)和海普西丁(p<；0.05)与脐血铁水平呈负相关。母体肥胖与母体-胎儿铁转移受损有关，可能是通过海普西丁上调。
To ascertain the effect of obesity-related inflammation on maternal and fetal iron status. We hypothesized that obese pregnant women would have increased inflammation, hepcidin levels, and that their infants would have impaired iron status compared to lean controls. Fifteen obese (Ob) and fifteen lean (Lc) women were recruited in their second trimester of pregnancy. Markers of iron status, inflammation and hepcidin were measured in maternal and cord blood. Student’s t test was used to compare obese and lean groups, and Pearson correlation coefficients were determined between maternal and cord blood values. Maternal C-reactive protein (CRP) (p<0.01) and hepcidin (p<0.01) were higher, and cord blood iron (p<0.01) was lower in the obese group. Maternal BMI (p<0.01) and hepcidin (p<0.05) were negatively correlated with cord blood iron status. Maternal obesity is associated with impaired maternal-fetal iron transfer, potentially through hepcidin upregulation.
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