Epidermal growth factor reduces hepatic sequelae in experimental necrotizing enterocolitis.
Epidermal growth factor reduces hepatic sequelae in experimental necrotizing enterocolitis.
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表皮生长因子可减少实验性坏死性小肠结肠炎的肝脏后遗症。
DOI：
10.1159/000090015
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Dvorak,Bohuslav
中科院分区：
文献类型：
--
作者：
Halpern,MelissaD;Holubec,Hana;Clark,JessicaA;Saunders,TaraA;Williams,CatherineS;Dvorak,Katerina;Dvorak,Bohuslav
Background and Aim:Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of premature infants. We recently demonstrated that the gut/liver axis plays an important role in the pathophysiology of NEC through the release of inflammatory mediators into the intestinal lumen. We have also shown that supplementation of formula with epidermal growth factor (EGF) dramatically decreases ileal pathology associated with experimental NEC. In this study, we examined the effects of EGF on the liver portion of the gut/liver axis in the neonatal rat model of NEC.Methods:Newborn rats were divided into three experimental groups, NEC, hand-fed with growth-factor free formula; NEC + EGF, hand-fed with formula supplemented with 500 ng/ml rat EGF; or DF, dam fed. All animals were exposed to asphyxia and cold stress twice daily for 4 days to develop NEC.Results:EGF receptor expression was significantly (p ≤ 0.01) decreased in the NEC + EGF group compared to the NEC group. EGF supplementation significantly decreased Kupffer cell numbers (p ≤ 0.01) as well as hepatic tumor necrosis factor (TNF)-α and interleukin-18 production (p ≤ 0.05). Further, TNF-α in the intestinal luminal contents of the NEC + EGF group were normalized to levels observed in DF controls compared to the NEC group (p ≤ 0.05). Activated nuclear factor-ĸB was also substantially decreased in the NEC + EGF group versus the NEC group.Conclusion:The results of this study indicate that EGF normalizes cytokine overproduction in the liver of neonatal rats with NEC, which contributes to diminished intestinal damage during the development of experimental NEC. These data suggest that supplementation of formula with EGF can have beneficial effects on the gut/liver axis during NEC pathogenesis.
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DOI：
--
发表时间：
1960
期刊：
Journal of Comparative and Physiological Psychology
影响因子：
--
作者：
M. H. Weasner;F. W. Finger;L. S. Reid
通讯作者：
L. S. Reid
DOI：
10.1093/geronj/40.6.657
发表时间：
1985-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
YU, BP;MASORO, EJ;MCMAHAN, CA
通讯作者：
MCMAHAN, CA
减少膳食摄入量对雄性大鼠随机和自愿活动的影响。
DOI：
--
发表时间：
1964
期刊：
Journal of Gerontology
影响因子：
--
作者：
D. Olewine;C. Barrows;N. Shock
通讯作者：
N. Shock
来自食物限制的啮齿动物模型的衰老糖化假说的证据。
DOI：
--
发表时间：
1989
期刊：
Journal of Gerontology
影响因子：
--
作者：
E. Masoro;Michael S. Katz;C. Mcmahan
通讯作者：
C. Mcmahan
影响因子：
3.6
作者：
J. Beattie;P. Herbert
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P. Herbert