Neuroprotective function of DJ-1 in Parkinson's disease.
Neuroprotective function of DJ-1 in Parkinson's disease.
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DOI：
10.1155/2013/683920
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发表时间：
2013
影响因子：
--
通讯作者：
Iguchi-Ariga SM
中科院分区：
文献类型：
--
作者：
Ariga H;Takahashi-Niki K;Kato I;Maita H;Niki T;Iguchi-Ariga SM
帕金森病 (PD) 是由黑质中的多巴胺能神经元死亡引起的，导致纹状体中的多巴胺水平降低。氧化应激和线粒体功能障碍被认为是帕金森病神经变性的主要原因。尽管遗传和环境因素被认为影响帕金森病的发病，但分子水平上的精确机制尚未阐明。 DJ-1基因是家族性PD（park7）的致病基因，也是癌基因。 DJ-1具有多种功能，包括转录调节、抗氧化应激反应以及分子伴侣、蛋白酶和线粒体调节，其活性受其氧化状态尤其是DJ-1的106位半胱氨酸(C106)的氧化状态调节。在散发性 PD 和阿尔茨海默病患者中观察到 DJ-1 过度氧化，导致 DJ-1 失活，这表明 DJ-1 也参与散发性 PD 以及家族性 PD 的发病和发病机制。 DJ-1 也是一种应激传感器，其表达在各种应激（包括氧化应激）下增加。在这篇综述中，我们描述了 DJ-1 对抗氧化应激的功能以及 DJ-1 在 PD 发病机制中的可能作用。
Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD. Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated. The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer's disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.
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影响因子：
6.1
作者：
Hauser DN;Hastings TG
通讯作者：
Hastings TG
DOI：
10.1073/pnas.0911175107
发表时间：
2010-05-25
影响因子：
11.1
作者：
Hao, Ling-Yang;Giasson, Benoit I.;Bonini, Nancy M.
通讯作者：
Bonini, Nancy M.
影响因子：
4.8
作者：
Honbou, K;Suzuki, NN;Inagaki, F
通讯作者：
Inagaki, F
影响因子：
56.9
作者：
Bonifati, V;Rizzu, P;Heutink, P
通讯作者：
Heutink, P
DOI：
10.1073/pnas.0607260103
发表时间：
2006-10-10
影响因子：
11.1
作者：
Clements, Casey M.;McNally, Richard S.;Ting, Jenny P-Y.
通讯作者：
Ting, Jenny P-Y.