SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses.
SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses.
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DOI：
10.1016/j.cell.2022.01.011
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发表时间：
2022-03-03
期刊：
影响因子：
64.5
通讯作者：
Veesler D
中科院分区：
文献类型：
--
作者：
Walls AC;Sprouse KR;Bowen JE;Joshi A;Franko N;Navarro MJ;Stewart C;Cameroni E;McCallum M;Goecker EA;Degli-Angeli EJ;Logue J;Greninger A;Corti D;Chu HY;Veesler D
尽管与未接种疫苗的个体相比，接种疫苗的个体感染导致的COVID-19症状较轻，但突破性病例引发的抗体反应的特异性和持久性仍然未知。在这里，我们证明了突破性感染诱导血清结合和中和抗体反应，这些抗体反应明显比仅接种两剂疫苗的受试者更有效、持久和适应变异中观察到的刺突突变。然而，我们发现突破病例、感染后接种疫苗的受试者和接种三次疫苗的个体具有相当的血清中和活性，这表明暴露于SARS-CoV-2抗原的次数增加可提高抗体反应的质量。然而，sars冠状病毒的中和作用是中等的，这强调了开发能引起广泛的sarbecovirus免疫的疫苗对大流行防范的重要性。突破COVID-19感染的个体、先前感染/接种疫苗的个体以及接种过三次疫苗的个体具有针对相关变异（包括Omicron）的强效血清结合抗体和中和抗体反应。然而，sars冠状病毒的中和作用是温和的，因此迫切需要开发用于大流行防范的广泛疫苗。
Although infections among vaccinated individuals lead to milder COVID-19 symptoms relative to those in unvaccinated subjects, the specificity and durability of antibody responses elicited by breakthrough cases remain unknown. Here, we demonstrate that breakthrough infections induce serum-binding and -neutralizing antibody responses that are markedly more potent, durable, and resilient to spike mutations observed in variants than those in subjects who received only 2 doses of vaccine. However, we show that breakthrough cases, subjects who were vaccinated after infection, and individuals vaccinated three times have serum-neutralizing activity of comparable magnitude and breadth, indicating that an increased number of exposures to SARS-CoV-2 antigen(s) enhance the quality of antibody responses. Neutralization of SARS-CoV was moderate, however, underscoring the importance of developing vaccines eliciting broad sarbecovirus immunity for pandemic preparedness. Individuals with breakthrough COVID-19 infections, previously infected/vaccinated individuals, and those vaccinated thrice have potent serum-binding and -neutralizing antibody responses against variants of concern, including Omicron. Neutralization of SARS-CoV, however, was moderate, thus urging the need for developing broad vaccines for pandemic preparedness.
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影响因子：
16.6
作者：
Li B;Deng A;Li K;Hu Y;Li Z;Shi Y;Xiong Q;Liu Z;Guo Q;Zou L;Zhang H;Zhang M;Ouyang F;Su J;Su W;Xu J;Lin H;Sun J;Peng J;Jiang H;Zhou P;Hu T;Luo M;Zhang Y;Zheng H;Xiao J;Liu T;Tan M;Che R;Zeng H;Zheng Z;Huang Y;Yu J;Yi L;Wu J;Chen J;Zhong H;Deng X;Kang M;Pybus OG;Hall M;Lythgoe KA;Li Y;Yuan J;He J;Lu J
通讯作者：
Lu J
影响因子：
56.9
作者：
Hsieh, Ching-Lin;Goldsmith, Jory A.;McLellan, Jason S.
通讯作者：
McLellan, Jason S.
DOI：
10.1016/j.xcrm.2021.100230
发表时间：
2021-04-20
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Hassan AO;Feldmann F;Zhao H;Curiel DT;Okumura A;Tang-Huau TL;Case JB;Meade-White K;Callison J;Chen RE;Lovaglio J;Hanley PW;Scott DP;Fremont DH;Feldmann H;Diamond MS
通讯作者：
Diamond MS
影响因子：
30.3
作者：
Case, James Brett;Rothlauf, Paul W.;Whelan, Sean P. J.
通讯作者：
Whelan, Sean P. J.
影响因子：
64.5
作者：
Corti D;Purcell LA;Snell G;Veesler D
通讯作者：
Veesler D