Cardiovascular effects of air pollution.
Cardiovascular effects of air pollution.
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DOI：
10.1016/j.acvd.2017.05.003
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发表时间：
2017-11
影响因子：
3
通讯作者：
Argacha JF
中科院分区：
文献类型：
--
作者：
Bourdrel T;Bind MA;Béjot Y;Morel O;Argacha JF
空气污染由颗粒物（PM）和气态污染物（如二氧化氮和臭氧）组成。PM根据大小分为粗颗粒（PM10）、细颗粒（PM2.5）和超细颗粒。我们的目的是提供一个原始的审查的科学证据，从流行病学和实验研究检查室外空气污染的心血管影响。汇总的流行病学研究报告称，PM2.5长期暴露增加10 μg/m3与心血管死亡率增加11%相关。心血管死亡率的增加也与长期和短期暴露于二氧化氮有关。暴露于空气污染和道路交通与动脉硬化的风险增加有关，如过早的主动脉和冠状动脉钙化所示。空气污染的短期增加与心肌梗死、中风和急性心力衰竭的风险增加有关。即使污染物浓度低于欧洲标准，风险也会增加。许多实验研究证实，空气污染会促进全身血管氧化应激反应，从而加强了流行病学研究的证据。自由基氧诱导内皮功能障碍、单核细胞活化和脂蛋白的某些致动脉粥样硬化变化，从而启动斑块形成。此外，空气污染有利于血栓形成，因为凝血因子和血小板活化增加。实验研究还表明，一些污染物对心血管的危害更大，如燃烧产生的PM2.5和超细颗粒物。空气污染是心血管疾病的主要诱因。促进更安全的空气质量似乎是预防心血管疾病的新挑战。
Air pollution is composed of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide and ozone. PM is classified according to size into coarse particles (PM10), fine particles (PM2.5) and ultrafine particles. We aim to provide an original review of the scientific evidence from epidemiological and experimental studies examining the cardiovascular effects of outdoor air pollution. Pooled epidemiological studies reported that a 10 μg/m3 increase in long-term exposure to PM2.5 was associated with an 11% increase in cardiovascular mortality. Increased cardiovascular mortality was also related to long-term and short-term exposure to nitrogen dioxide. Exposure to air pollution and road traffic was associated with an increased risk of arteriosclerosis, as shown by premature aortic and coronary calcification. Short-term increases in air pollution were associated with an increased risk of myocardial infarction, stroke and acute heart failure. The risk was increased even when pollutant concentrations were below European standards. Reinforcing the evidence from epidemiological studies, numerous experimental studies demonstrated that air pollution promotes a systemic vascular oxidative stress reaction. Radical oxygen species induce endothelial dysfunction, monocyte activation and some proatherogenic changes in lipoproteins, which initiate plaque formation. Furthermore, air pollution favours thrombus formation, because of an increase in coagulation factors and platelet activation. Experimental studies also indicate that some pollutants have more harmful cardiovascular effects, such as combustion-derived PM2.5 and ultrafine particles. Air pollution is a major contributor to cardiovascular diseases. Promotion of safer air quality appears to be a new challenge in cardiovascular disease prevention.
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DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
10
作者：
Atkinson RW;Kang S;Anderson HR;Mills IC;Walton HA
通讯作者：
Walton HA
影响因子：
2.9
作者：
Atkinson RW;Butland BK;Dimitroulopoulou C;Heal MR;Stedman JR;Carslaw N;Jarvis D;Heaviside C;Vardoulakis S;Walton H;Anderson HR
通讯作者：
Anderson HR
影响因子：
10.4
作者：
Fuks KB;Weinmayr G;Foraster M;Dratva J;Hampel R;Houthuijs D;Oftedal B;Oudin A;Panasevich S;Penell J;Sommar JN;Sørensen M;Tiittanen P;Wolf K;Xun WW;Aguilera I;Basagaña X;Beelen R;Bots ML;Brunekreef B;Bueno-de-Mesquita HB;Caracciolo B;Cirach M;de Faire U;de Nazelle A;Eeftens M;Elosua R;Erbel R;Forsberg B;Fratiglioni L;Gaspoz JM;Hilding A;Jula A;Korek M;Krämer U;Künzli N;Lanki T;Leander K;Magnusson PK;Marrugat J;Nieuwenhuijsen MJ;Ostenson CG;Pedersen NL;Pershagen G;Phuleria HC;Probst-Hensch NM;Raaschou-Nielsen O;Schaffner E;Schikowski T;Schindler C;Schwarze PE;Søgaard AJ;Sugiri D;Swart WJ;Tsai MY;Turunen AW;Vineis P;Peters A;Hoffmann B
通讯作者：
Hoffmann B
影响因子：
3.5
作者：
Argacha, J. F.;Collart, P.;Claeys, M. J.
通讯作者：
Claeys, M. J.