Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).
Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).
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DOI：
10.1289/ehp.1307725
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发表时间：
2014-09
影响因子：
10.4
通讯作者：
Hoffmann B
中科院分区：
文献类型：
--
作者：
Fuks KB;Weinmayr G;Foraster M;Dratva J;Hampel R;Houthuijs D;Oftedal B;Oudin A;Panasevich S;Penell J;Sommar JN;Sørensen M;Tiittanen P;Wolf K;Xun WW;Aguilera I;Basagaña X;Beelen R;Bots ML;Brunekreef B;Bueno-de-Mesquita HB;Caracciolo B;Cirach M;de Faire U;de Nazelle A;Eeftens M;Elosua R;Erbel R;Forsberg B;Fratiglioni L;Gaspoz JM;Hilding A;Jula A;Korek M;Krämer U;Künzli N;Lanki T;Leander K;Magnusson PK;Marrugat J;Nieuwenhuijsen MJ;Ostenson CG;Pedersen NL;Pershagen G;Phuleria HC;Probst-Hensch NM;Raaschou-Nielsen O;Schaffner E;Schikowski T;Schindler C;Schwarze PE;Søgaard AJ;Sugiri D;Swart WJ;Tsai MY;Turunen AW;Vineis P;Peters A;Hoffmann B
背景：长期暴露于空气污染被认为会升高动脉血压（BP）。现有的证据很少，而且针对具体国家。目的：我们调查了欧洲人群中长期交通相关空气污染与BP和高血压患病率的横断面相关性。方法：我们分析了15个基于人群的队列，参与了欧洲空气污染影响队列研究（ESCAPE）。我们模拟住宅暴露于颗粒物和氮氧化物与土地利用回归使用统一的协议。我们评估了交通指标变量的交通暴露。我们分析了收缩压和舒张压与降压药物（BPLM）的药物治疗和非药物治疗的参与者分别调整个人和地区水平的危险因素和环境噪音。高血压患病率定义为收缩压≥ 140 mmHg或舒张压≥ 90 mmHg或摄入BPLM。我们使用随机效应荟萃分析结合了队列特异性结果。结果如下：在对113，926名受试者进行的主要荟萃分析中，住所100 m范围内主要道路的交通负荷与未用药受试者的收缩压和舒张压升高相关[分别为0.35 mmHg（95% CI：0.02，0.68）和0.22 mmHg（95% CI：0.04，0.40）/4，000，000辆车× m/天]。估计的患病高血压的比值比（OR）为1.05（95% CI：0.99，1.11）/4，000，000辆车× m/天。模拟的空气污染物和BP没有明确的相关性。结论：在欧洲人群队列的第一次综合荟萃分析中，我们观察到高住宅交通暴露与非药物参与者的BP呈弱正相关，并且患病高血压的OR升高。模拟的空气污染物与BP的关系不一致。引文：Fuks KB，Weinmayr G，Foraster M，Dratva J，Hampel R，Houthuijs D，Oftedal B，Oudin A，Panasevich S，Penell J，Sommar JN，Sørensen M，Tittanen P，Wolf K，Xun WW，Aguilera I，Basagaña X，比伦R，Bots ML，Brunekreef B，Bueno-de-Mesquita HB，Caracciolo B，Cirach M，de Faire U，de Nazelle A，Eeftens M，Elosua R，Erbel R，Forsberg B，Fratiglioni L，Gaspoz JM，Hilding A，Jula A，Korek M，Krämer U，Künzli N，Lanki T，Leander K，Magnusson PK，Marrugat J，Nieuwenhuijsen MJ，Östenson CG，Pedersen NL，Pershagen G，Phuleria HC，Probst-Hensch NM，Raaschou-Nielsen O，Schaffner E，Schikowski T，Schindler C，Schwarze PE，Søgaard AJ，Sugiri D，Swart WJ，Tsai MY，Turunen AW，Vineis P，Peters A，Hoffmann B. 2014.动脉血压和长期暴露于交通相关的空气污染：欧洲空气污染影响队列研究（ESCAPE）的分析。环境健康展望122：896-905; http：dx.doi.org/10.1289/ehp.1307725
Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. Methods: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. Results: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated. Conclusions: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent. Citation: Fuks KB, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, Oftedal B, Oudin A, Panasevich S, Penell J, Sommar JN, Sørensen M, Tittanen P, Wolf K, Xun WW, Aguilera I, Basagaña X, Beelen R, Bots ML, Brunekreef B, Bueno-de-Mesquita HB, Caracciolo B, Cirach M, de Faire U, de Nazelle A, Eeftens M, Elosua R, Erbel R, Forsberg B, Fratiglioni L, Gaspoz JM, Hilding A, Jula A, Korek M, Krämer U, Künzli N, Lanki T, Leander K, Magnusson PK, Marrugat J, Nieuwenhuijsen MJ, Östenson CG, Pedersen NL, Pershagen G, Phuleria HC, Probst-Hensch NM, Raaschou-Nielsen O, Schaffner E, Schikowski T, Schindler C, Schwarze PE, Søgaard AJ, Sugiri D, Swart WJ, Tsai MY, Turunen AW, Vineis P, Peters A, Hoffmann B. 2014. Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect 122:896–905; http://dx.doi.org/10.1289/ehp.1307725
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影响因子：
5.4
作者：
Gan, Wen Qi;Tamburic, Lillian;Brauer, Michael
通讯作者：
Brauer, Michael
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
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作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
8.3
作者：
Johnson, Derek;Parker, Jennifer D.
通讯作者：
Parker, Jennifer D.
影响因子：
37.8
作者：
Hoffmann, B.;Moebus, S.;Joeckel, K.-H.
通讯作者：
Joeckel, K.-H.
影响因子：
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作者：
COOK, NR;COHEN, J;HENNEKENS, CH
通讯作者：
HENNEKENS, CH