Comparison of Ultra-Widefield Imaging and Standard Imaging in Assessment of Early Treatment Diabetic Retinopathy Severity Scale.
Comparison of Ultra-Widefield Imaging and Standard Imaging in Assessment of Early Treatment Diabetic Retinopathy Severity Scale.
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超广角成像与标准成像在早期治疗糖尿病视网膜病变严重程度评估中的比较。
DOI：
10.1016/j.xops.2021.100029
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发表时间：
2021-06
影响因子：
--
通讯作者：
Blodi, Barbara
中科院分区：
文献类型：
--
作者：
Domalpally, Amitha;Barrett, Nancy;Reimers, James;Blodi, Barbara
关键词：
比较早期治疗糖尿病视网膜病变研究(ETDRS)标准7视野成像和超宽视野(UWF)成像的严重程度，并将周围型糖尿病视网膜病变(DR)病变纳入ETDRS分级系统。横断面研究。研究对象包括192只眼(189名参与者)的糖尿病视网膜病变患者的配对图像。标准7野成像、7野UWF成像(7野UWF成像)和整个UWF图像(全球ETDRS成像)通过3种方式确定ETDRS水平。ETDRS水平的7场成像和UWF成像之间的百分比一致性。在评估的16 6对图像中，48.8%的眼标准7视野和7视野UWF ETDRS水平完全一致，加权κ值为0.5 9(95%可信区间0.5~0.6 8)。符合率随DR严重程度的不同而不同，早期DR(30.8%)和中度非增殖性DR(26.5%)组的符合率最低。在7视野UWF ETDRS与全球UWF ETDRS水平的15 6只眼中，有14 3只眼(92%)符合，加权κ值为0.9(95%CI，0.9~0.98)。外周病变导致8%的糖尿病视网膜病变加重，2%的患者眼部改变为增生性糖尿病视网膜病变。3ETDRS评估的重复性与标准7野成像的加权κ值0.57、7野UWF成像的0.65和全球ETDRS分级成像的0.60相当。在标准7野和UWF成像的ETDRS DR严重程度分级中发现中等程度的一致性，这表明在交换来自两种方法的数据时要谨慎。两种方法对两步改变的临床试验结果均显示出良好的重复性。全球ETDRS量表提供了将外围变化纳入ETDRS量表的综合评分。全球规模对进展率的影响尚未确定。
To compare Early Treatment Diabetic Retinopathy Study (ETDRS) severity levels between standard 7-field imaging and ultra-widefield (UWF) imaging and to incorporate peripheral diabetic retinopathy (DR) lesions into the ETDRS grading system. Cross-sectional Study. Paired images from 192 eyes (189 participants) with diabetic retinopathy were included. The ETDRS levels were determined by masked graders in 3 ways: standard 7-field imaging, UWF within the 7-field region (7-field UWF imaging), and the entire UWF image (global ETDRS imaging). Percentage agreement between 7-field and UWF imaging for ETDRS levels. Of the 166 paired images evaluated, exact agreement was found in 48.8% of eyes between standard 7-field and 7-field UWF ETDRS levels with a weighted κ value of 0.59 (95% confidence interval [CI], 0.5–0.68). Agreement rates varied with DR severity and were least in early DR (30.8%) and moderate nonproliferative DR (26.5%) groups. In 156 eyes with 7-field UWF ETDRS and global UWF ETDRS levels, exact agreement was found in 143 eyes (92%), with a weighted κ value of 0.9 (95% CI, 0.9–0.98). The peripheral lesions contributed to a higher DR severity in 8% and changed the eye to a proliferative DR level in 2%. Reproducibility of the 3 ETDRS evaluations was comparable with a weighted κ value of 0.57 with standard 7-field imaging, 0.65 with 7-field UWF imaging, and 0.60 with global ETDRS scale imaging. Moderate agreement was found in the ETDRS DR severity scale between standard 7-field and UWF imaging, indicating caution in interchanging data from the 2 methods. Both methods showed good reproducibility for clinical trial outcome of 2-step change. The global ETDRS scale provides a comprehensive score to incorporate peripheral changes into the ETDRS scale. The implications of the global scale on progression rate are yet to be determined.
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DOI：
10.1136/bjophthalmol-2015-306719
发表时间：
2015-12
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Talks SJ;Manjunath V;Steel DH;Peto T;Taylor R
通讯作者：
Taylor R
DOI：
10.2307/2987937
发表时间：
1983-01-01
期刊：
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES D-THE STATISTICIAN
影响因子：
--
作者：
ALTMAN, DG;BLAND, JM
通讯作者：
BLAND, JM
影响因子：
13.7
作者：
Domalpally, Amitha;Clemons, Traci E.;Chew, Emily Y.
通讯作者：
Chew, Emily Y.
DOI：
10.2147/opth.s79448
发表时间：
2015
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Price LD;Au S;Chong NV
通讯作者：
Chong NV
影响因子：
8.1
作者：
Sears, Connie Martin;Nittala, Muneeswar G.;Sadda, SriniVas R.
通讯作者：
Sadda, SriniVas R.