Category-specific occipitotemporal activation during face perception in dyslexic individuals: an MEG study
Category-specific occipitotemporal activation during face perception in dyslexic individuals: an MEG study
复制标题
阅读障碍者面部感知过程中类别特异性枕颞叶激活：一项 MEG 研究
DOI：
10.1016/s1053-8119(03)00161-7
复制
发表时间：
2003
期刊：
影响因子：
5.7
通讯作者：
R. Salmelin
中科院分区：
文献类型：
--
作者：
A. Tarkiainen;P. Helenius;R. Salmelin
在阅读障碍中，人们一致发现字母串在左枕颞叶皮质中产生异常微弱的反应或没有反应。时间敏感成像技术已将这种缺陷定位到刺激呈现后约 150 毫秒的特定类别处理阶段。通常报道的阅读障碍行为障碍表明枕颞叶激活的缺乏是阅读所特有的。然而，它也可能反映左下枕颞皮质或特定类别激活的时间窗口（150 至 200 毫秒）的更普遍的功能障碍。由于面部的早期皮质处理在位置和时间上都遵循与字母串几乎相同的序列，因此我们通过比较阅读障碍和非阅读障碍受试者的面部特异性枕颞叶激活来研究这些可能性。我们发现，在阅读困难个体中，大约 100 毫秒的一般视觉特征分析阶段和大约 150 毫秒的最早面部特异性激活基本上都是正常的。目前的结果强调了阅读障碍中枕颞区字母串异常的特殊性。然而，在行为测试中，有阅读障碍的受试者在判断面部和几何形状的相似性方面比非阅读障碍受试者更慢且更容易出错。这种效应可能与刺激开始后 250 毫秒左右右侧顶颞叶皮层的激活减少有关。
In dyslexia, it is consistently found that letter strings produce an abnormally weak or no response in the left occipitotemporal cortex. Time-sensitive imaging techniques have located this deficit to the category-specific processing stage at about 150 ms after stimulus presentation. The typically reported behavioral impairments in dyslexia suggest that the lack of occipitotemporal activation is specific to reading. It could, however, also reflect a more general dysfunction in the left inferior occipitotemporal cortex or in the time window of category-specific activation (150 to 200 ms). As early cortical processing of faces follows a sequence practically identical to that for letter strings, both in location and in timing, we investigated these possibilities by comparing face-specific occipitotemporal activations in dyslexic and non-reading-impaired subjects. We found that both the stage of general visual feature analysis at about 100 ms and the earliest face-specific activation at about 150 ms were essentially normal in the dyslexic individuals. The present results emphasize the special nature of the occipitotemporal abnormality to letter strings in dyslexia. However, in behavioral tests dyslexic subjects were slower and more error-prone than non-reading-impaired subjects in judging the similarity of faces and geometrical shapes. This effect may be related to reduced activation of the right parietotemporal cortex at about 250 ms after stimulus onset.
影响因子：
3.7
作者：
Halgren, E;Raij, T;Hari, R
通讯作者：
Hari, R
DOI：
10.1073/pnas.95.5.2636
发表时间：
1998-03-03
影响因子：
11.1
作者：
Shaywitz, SE;Shaywitz, BA;Gore, JC
通讯作者：
Gore, JC