High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population.
High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population.
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DOI：
10.4049/jimmunol.0803474
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发表时间：
2010-07-01
期刊：
影响因子：
--
通讯作者：
Wedderburn LR
中科院分区：
文献类型：
--
作者：
Moncrieffe H;Nistala K;Kamhieh Y;Evans J;Eddaoudi A;Eaton S;Wedderburn LR
外核苷酸酶CD 39最近被描述为在调节性Foxp 3 + CD 4 T细胞上高度表达。通过促炎细胞外ATP的水解，CD 39活性代表了一种新描述的调节性T细胞作用机制。我们报道了一种新的表达CD 39但Foxp 3阴性的人CD 4 T细胞群体。这些细胞产生促炎细胞因子IFN-γ和IL-17，并且不能抑制增殖;然而，它们仍然具有高ATP水解活性。在人类幼年特发性关节炎的炎症部位，与患者或健康对照的外周血相比，CD 39 + Foxp 3 −群体大大增加。我们还表明，表达AMPase CD 73的细胞在关节中的频率低于血液。据我们所知，这是第一项描述和表征人类自身炎症条件下靶位点CD 4 T细胞上CD 39功能的研究。我们的数据表明，在人类CD 4 + T细胞从发炎的网站，CD 39可以高度表达的两个群体，一个调节和其他的记忆表型。
The ectonucleotidase CD39 has recently been described as being highly expressed on regulatory Foxp3+ CD4 T cells. Through hydrolysis of proinflammatory extracellular ATP, CD39 activity represents a newly described mechanism of regulatory T cell action. We report a novel population of human CD4 T cells that express CD39 yet are Foxp3 negative. These cells produce the proinflammatory cytokines IFN-γ and IL-17 and fail to suppress proliferation; however, they still have high ATP hydrolysis activity. In the inflammatory site in human juvenile idiopathic arthritis, the CD39+Foxp3− population is greatly increased compared with peripheral blood of patients or healthy controls. We also show that cells expressing the AMPase CD73 are less frequent in the joint than in blood. To our knowledge, this is the first study to describe and characterize CD39 function on CD4 T cells from the target site in a human autoinflammatory condition. Our data suggest that in human CD4+ T cells from the inflamed site, CD39 can be highly expressed on two populations, one regulatory and the other of a memory phenotype.
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DOI：
10.1084/jem.194.6.847
发表时间：
2001-09-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Iellem A;Mariani M;Lang R;Recalde H;Panina-Bordignon P;Sinigaglia F;D'Ambrosio D
通讯作者：
D'Ambrosio D
CD127表达与FOXP3和人类CD4+ T Reg细胞的抑制功能成反比。
DOI：
10.1084/jem.20060772
发表时间：
2006-07-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten
DOI：
10.1006/bbrc.2000.2410
发表时间：
2000-04-02
影响因子：
3.1
作者：
Imai, M;Goepfert, C;Robson, SC
通讯作者：
Robson, SC
头颈癌患者调节性 T 细胞中的核酸外切酶表达和活性增加。
影响因子：
11.5
作者：
Mandapathil, Magis;Szczepanski, Miroslaw J.;Szajnik, Marta;Ren, Jin;Lenzner, Diana E.;Jackson, Edwin K.;Gorelik, Elieser;Lang, Stephan;Johnson, Jonas T.;Whiteside, Theresa L.
通讯作者：
Whiteside, Theresa L.