Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.
Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.
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DOI：
10.3349/ymj.2020.61.10.860
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发表时间：
2020-10
影响因子：
2.4
通讯作者：
Kim MC
中科院分区：
文献类型：
--
作者：
Kang MK;Park JG;Kim MC
非酒精性脂肪性肝病(NAFLD)与房颤(AF)的发生独立相关。然而，在NAFLD患者中，房颤与进展性肝纤维化的相关性尚未建立，后者与全因、心血管和肝脏相关的死亡率有关。我们的目的是研究房颤与NAFLD患者晚期肝纤维化的关系。在参与健康检查计划的53704名成年人中，6,293名年龄在35岁及以上的受试者被超声诊断为非酒精性脂肪肝。根据新调整的NAFLD纤维化评分(NFS)和纤维化-4指数(Fib-4)来评估肝纤维化的分期，这两项指标被用来确定肝纤维化的低和高临界值(CoV)。在6293例NAFLD患者中，59例(0.9%)被诊断为房颤。房颤患者的年龄(52.0vs.64.6岁，p<；0.001)、体重指数(25.2vs.26.6 kg/m2，p<；0.001)和腰围(84.0vs.89.9 cm，p<；0.001)均高于非房颤患者。在非酒精性脂肪肝患者中，房颤与晚期肝纤维化独立相关，用两个非酒精性肝病的COV进行评估[低COV组：最终调整后优势比(AORS)=2.85，p=0.004；高COV组：ORS=12.29p<；0.001)。使用FIB-4的两种COV进行评估，房颤与晚期肝纤维化独立相关(低COV组：AORS=2.49，P=0.001；高COV组：AORS=3.84，P=0.016)。房颤与NAFLD患者的晚期肝纤维化独立相关。
Non-alcoholic fatty liver disease (NAFLD) is independently associated with the development of atrial fibrillation (AF). However, the association of AF with advanced liver fibrosis, which is related to all-cause, cardiovascular, and liver-related mortality, has not been established in NAFLD patients. We aimed to investigate the association between AF and advanced liver fibrosis in NAFLD patients. Out of 53704 adults who participated in the health check-up program, 6293 subjects aged 35 years and older were diagnosed as NAFLD using ultrasound. The stage of liver fibrosis was assessed based on the newly adjusted NAFLD fibrosis score (NFS) and Fibrosis-4 (Fib-4) Index, which were used to determine the low and high cut-off values (COVs). Of 6293 patients with NAFLD, 59 (0.9%) were diagnosed with AF. Patients with AF were older (52.0 vs. 64.6 years, p<0.001), had higher body mass index (25.2 vs. 26.6 kg/m2, p<0.001), and had bigger waist circumference (84.0 vs. 89.9 cm, p<0.001) than those without AF. In NAFLD patients, AF was independently associated with advanced liver fibrosis, assessed using both COVs of NFS [low-COV group: final adjusted odds ratios (aORs)=2.85, p=0.004; high-COV group: ORs=12.29, p<0.001). AF was independently associated with advanced liver fibrosis, assessed using both COVs of Fib-4 (low-COV group: aORs=2.49, p<0.001; high-COV group: aORs=3.84, p=0.016). AF is independently associated with advanced liver fibrosis in patients with NAFLD.
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非酒精性脂肪肝病患者的纤维化无创评估。
影响因子：
2.8
作者：
Buzzetti E;Lombardi R;De Luca L;Tsochatzis EA
通讯作者：
Tsochatzis EA
非酒精性脂肪肝病的影响对由时域，频域和心率变异性的符号动态评估的自主变化的影响。
影响因子：
3.7
作者：
Liu YC;Hung CS;Wu YW;Lee YC;Lin YH;Lin C;Lo MT;Chan CC;Ma HP;Ho YL;Chen CH
通讯作者：
Chen CH
影响因子：
3.7
作者：
Lee YH;Bang H;Park YM;Bae JC;Lee BW;Kang ES;Cha BS;Lee HC;Balkau B;Lee WY;Kim DJ
通讯作者：
Kim DJ
影响因子：
6.1
作者：
Kirchhof, Paulus;Benussi, Stefano;Zeppenfeld, Katja
通讯作者：
Zeppenfeld, Katja
影响因子：
29.4
作者：
Angulo P;Kleiner DE;Dam-Larsen S;Adams LA;Bjornsson ES;Charatcharoenwitthaya P;Mills PR;Keach JC;Lafferty HD;Stahler A;Haflidadottir S;Bendtsen F
通讯作者：
Bendtsen F