Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation.
Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation.
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DOI：
10.1177/10760296211054514
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Elgheriany W
中科院分区：
文献类型：
--
作者：
Efat A;Shoeib S;Nazir A;Abdelmohsen E;Dawod A;Bedair HM;Elgheriany W
免疫性血小板减少症（ITP）似乎是一种异质性疾病。在某些患者中，自身免疫可能与炎症过程相关，而在其他患者中，低血小板可能会干扰凝血系统的其他方面。任何一种都可能易患血栓形成或出血。进一步研究血小板与炎性细胞因子和内皮生物标志物的相互作用，可能有助于我们更好地了解这种疾病，并识别有出血风险的患者，或相反的血栓形成。这项工作的目的是估计血管性血友病因子（vWF）和血管细胞粘附分子（V-CAM）血清水平在成人免疫性血小板减少症（ITP）患者，并破译其可能的临床相关性。80名成人（≥ 18岁）入组研究; 40名初治新诊断的原发性ITP患者（根据ASH 2019）和40名性别和年龄匹配的健康对照，所有组均接受全血细胞计数（CBC）、肝脏和肾功能检查、ESR、CRP、V-CAM和VWF-Ag（酶联免疫吸附试验（ELISA））。在VWF-Ag和V-CAM的平均水平方面，病例组和对照组之间存在高度统计学显著性差异。vWF和V-CAM可作为内皮细胞改变的生物标志物，应作为血小板减少性出血的预测因子进行研究，并相应地调整患者治疗。
Immune thrombocytopenia (ITP) appears to be a heterogeneous disease. In some patients, autoimmunity may be associated with an inflammatory process, and in other patients, low platelets may interfere with other aspects of the coagulation system. Either may predispose to thrombosis or bleeding. Further investigation of the interactions of platelets, with inflammatory cytokines and endothelial biomarkers, may help us to better understand the disease, and to recognize those patients at risk of bleeding, or conversely thrombosis. The aim of this work is to estimate von Willebrand factor (vWF) and vascular cellular adhesion molecule (V-CAM) serum levels in adult immune thrombocytopenic patients (ITP) and to decipher their possible clinical correlates. Eighty adults (≥ 18 years) were enrolled in the study; naive newly diagnosed 40 patients with primary ITP (according to the ASH 2019) and 40 sex and age-matched healthy controls, all groups are subjected for complete blood count (CBC), liver, and renal function tests, ESR, CRP, V-CAM, and VWF-Ag by enzyme-linked immunosorbent assay (ELISA). There was a highly statistically significant difference between case and control as regards to the mean level of VWF-Ag and V-CAM. vWF and V-CAM could serve as biomarkers for endothelial alterations and should be investigated as a predictor of thrombocytopenic bleeding and tailor patient management accordingly.
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影响因子：
2.9
作者：
Baimukanova G;Miyazawa B;Potter DR;Muench MO;Bruhn R;Gibb SL;Spinella PC;Cap AP;Cohen MJ;Pati S
通讯作者：
Pati S
影响因子：
6.5
作者：
GILTAY, JC;BRINKMAN, HJM;VONDEMBORNE, AEGK
通讯作者：
VONDEMBORNE, AEGK
内皮细胞损伤如何开始？内皮素在系统性硬化症中的作用。
影响因子：
4.9
作者：
Abraham, David;Distler, Oliver
通讯作者：
Distler, Oliver
DOI：
10.1056/nejmra0800887
发表时间：
2008-09-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Nachman RL;Rafii S
通讯作者：
Rafii S
DOI：
10.3324/haematol.2011.043042
发表时间：
2011-08-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Santimone, Iolanda;Di Castelnuovo, Augusto;Iacoviello, Licia
通讯作者：
Iacoviello, Licia