odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
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DOI：
10.1242/dev.022830
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Drummond IA
中科院分区：
文献类型：
--
作者：
Mudumana SP;Hentschel D;Liu Y;Vasilyev A;Drummond IA
The kidney and vasculature are intimately linked functionally and during development, where nephric and blood/vascular progenitor cells occupy adjacent bands of mesoderm in zebrafish and frog embryos. Developmental mechanisms underlying the differentiation of kidney vs. blood/vascular lineages remain unknown. The odd skipped related1 (osr1) gene encodes a zinc finger transcription factor that is expressed in the germ ring mesendoderm and subsequently in the endoderm and intermediate mesoderm, prior to the expression of definitive kidney or blood/vascular markers. Knockdown of osr1 in zebrafish embryos resulted in a complete, segment-specific loss of anterior kidney progenitors and a compensatory increase in the number of angioblast cells in the same trunk region. Histology revealed a subsequent absence of kidney tubules, enlarged cardinal vein, and expansion of the posterior venous plexus. Altered kidney vs. vascular development correlated with expanded endoderm development in osr1 knockdowns. Combined osr1 loss of function and blockade of endoderm development by knockdown of sox32/casanova rescued anterior kidney development. The results indicate that osr1 activity is required to limit endoderm differentiation from mesendoderm and, in the absence of osr1, excess endoderm alters mesoderm differentiation, shifting the balance from kidney toward vascular development.
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影响因子：
9.2
作者：
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通讯作者：
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