Rejuvenation of regeneration in the aging central nervous system.
Rejuvenation of regeneration in the aging central nervous system.
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DOI：
10.1016/j.stem.2011.11.019
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发表时间：
2012-01-06
期刊：
影响因子：
23.9
通讯作者：
Franklin, Robin J. M.
中科院分区：
文献类型：
--
作者：
Ruckh, Julia M.;Zhao, Jing-Wei;Shadrach, Jennifer L.;van Wijngaarden, Peter;Rao, Tata Nageswara;Wagers, Amy J.;Franklin, Robin J. M.
再髓鞘形成是中枢神经系统（CNS）中的再生过程，其从成体干细胞产生新的髓鞘。随着年龄的增长而发生的髓鞘再生的下降对CNS中的治疗构成了显著的障碍，特别是对于长期脱髓鞘疾病如多发性硬化症（MS）。在这里，我们表明，实验诱导的脱髓鞘髓鞘的髓鞘再生是通过异时共生在老年小鼠暴露于年轻的全身环境增强。在老年动物中恢复髓鞘再生涉及从年轻的联体伙伴中招募血液来源的单核细胞修复病变，并且阻止这种招募部分抑制髓鞘再生的恢复。这些数据表明，增强的髓鞘再生活性需要年轻的单核细胞和其他因素，并且靶向内源性细胞的髓鞘再生增强疗法可以在整个生命过程中有效。
Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally-induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.
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影响因子：
14.5
作者：
Baer, Alexandra S.;Syed, Yasir A.;Kang, Sung Ung;Mitteregger, Dieter;Vig, Raluca;Ffrench-Constant, Charles;Franklin, Robin J. M.;Altmann, Friedrich;Lubec, Gert;Kotter, Mark R.
通讯作者：
Kotter, Mark R.
影响因子：
5.3
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Lo, Eng H.
影响因子：
3.5
作者：
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通讯作者：
Franklin, RJM
影响因子：
5.3
作者：
Sim, FJ;Zhao, C;Franklin, RJM
通讯作者：
Franklin, RJM
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA