NCLX: the mitochondrial sodium calcium exchanger.
NCLX: the mitochondrial sodium calcium exchanger.
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NCLX：线粒体钠钙交换器。
DOI：
10.1016/j.yjmcc.2013.03.012
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发表时间：
2013-06
影响因子：
5
通讯作者：
Lederer, W. J.
中科院分区：
文献类型：
--
作者：
Boyman, Liron;Williams, George S. B.;Khananshvili, Daniel;Sekler, Israel;Lederer, W. J.
线粒体基质内的游离Ca 2+浓度（[Ca 2 +]m）调节ATP产生速率和其他[Ca 2 +]m敏感过程。它由总Ca 2+内流（通过线粒体Ca 2+单向转运体（MCU）和任何其他内流途径）和总Ca 2+外流（通过线粒体Na+/Ca 2+交换体和任何其他外流途径）之间的平衡设定。在这里，我们回顾和分析的实验证据报告在过去的40年中，这表明在心脏和许多其他哺乳动物组织的一个假定的Na+/Ca 2+交换是Ca 2+流出线粒体基质的主要途径。我们讨论了这些报告，最近发现，人类FLJ 22233基因的蛋白质产物介导这样的Na+/Ca 2+交换线粒体内膜。在其与其他Na+/Ca 2+交换蛋白的许多功能相似性中，有一个独特的功能：它有效地介导Li+/Ca 2+交换（以及Na+/Ca 2+交换），因此被命名为NCLX。NCLX的发现提供了一种新的蛋白质的身份和新的分子手段，研究各种未解决的定量方面的线粒体Ca 2+运动的矩阵。NCLX的定量和定性特征进行了讨论，因为是关于NCLX Na+/Ca 2+交换的化学计量的争议，NCLX的产电性，NCLX的[Na+]i依赖性和NCLX Ca 2+流出的幅度。代谢功能归因于NCLX和生理意义的Ca 2+流出率通过NCLX在收缩期和舒张期也进行了简要讨论。
The free Ca2+ concentration within the mitochondrial matrix ([Ca2+]m) regulates the rate of ATP production and other [Ca2+]m sensitive processes. It is set by the balance between total Ca2+ influx (through the mitochondrial Ca2+ uniporter (MCU) and any other influx pathways) and the total Ca2+ efflux (by the mitochondrial Na+/Ca2+ exchanger and any other efflux pathways). Here we review and analyze the experimental evidence reported over the past 40 years which suggest that in the heart and many other mammalian tissues a putative Na+/Ca2+ exchanger is the major pathway for Ca2+ efflux from the mitochondrial matrix. We discuss those reports with respect to a recent discovery that the protein product of the human FLJ22233 gene mediates such Na+/Ca2+ exchange across the mitochondrial inner membrane. Among its many functional similarities to other Na+/Ca2+ exchanger proteins is a unique feature: it efficiently mediates Li+/Ca2+ exchange (as well as Na+/Ca2+ exchange) and was therefore named NCLX. The discovery of NCLX provides both the identity of a novel protein and new molecular means of studying various unresolved quantitative aspects of mitochondrial Ca2+ movement out of the matrix. Quantitative and qualitative features of NCLX are discussed as is the controversy regarding the stoichiometry of the NCLX Na+/Ca2+ exchange, the electrogenicity of NCLX, the [Na+]i dependency of NCLX and the magnitude of NCLX Ca2+ efflux. Metabolic features attributable to NCLX and the physiological implication of the Ca2+ efflux rate via NCLX during systole and diastole are also briefly discussed.
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影响因子：
4.1
作者：
CARAFOLI, E;LEHNINGE.AL
通讯作者：
LEHNINGE.AL
影响因子：
4.8
作者：
Cai, XJ;Lytton, J
通讯作者：
Lytton, J
影响因子：
64.8
作者：
Baughman, Joshua M.;Perocchi, Fabiana;Girgis, Hany S.;Plovanich, Molly;Belcher-Timme, Casey A.;Sancak, Yasemin;Bao, X. Robert;Strittmatter, Laura;Goldberger, Olga;Bogorad, Roman L.;Koteliansky, Victor;Mootha, Vamsi K.
通讯作者：
Mootha, Vamsi K.
影响因子：
5.5
作者：
BASSANI, JWM;BASSANI, RA;BERS, DM
通讯作者：
BERS, DM
影响因子：
3.4
作者：
BERLIN, JR;BASSANI, JWM;BERS, DM
通讯作者：
BERS, DM