Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in Sweden.
Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in Sweden.
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DOI：
10.1001/archgenpsychiatry.2010.33
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发表时间：
2010-05
影响因子：
--
通讯作者：
Lichtenstein, Paul
中科院分区：
文献类型：
--
作者：
D'Onofrio, Brian M.;Singh, Amber L.;Iliadou, Anastasia;Lambe, Mats;Hultman, Christina M.;Grann, Martin;Neiderhiser, Jenae M.;Langstrom, Niklas;Lichtenstein, Paul
母亲在怀孕期间吸烟（SDP）和后代的破坏性行为之间的关联已经得到了很好的证明，但目前还不清楚是否暴露于SDP或与SDP相关的因素的影响占风险增加。通过控制测量的协变量和使用准实验方法，测试SDP和后代刑事定罪之间的关联是否与因果关系一致，或由于家庭背景因素。我们对1983-1989年在瑞典出生的儿童（N= 609，372）进行了一项基于人群的研究，以检查SDP与后代犯罪信念之间的关联，同时控制父母双方的测量特征。我们还比较了不同暴露于SDP的兄弟姐妹（N= 50，339），以解释可能导致这种关联的未测量的家族因素。以人口为基础的研究，1983年至1989年在瑞典出生的所有儿童的母亲SDP和后代的刑事定罪的信息，根据国家登记处收集的瑞典政府。暴力和非暴力定罪，根据瑞典国家犯罪登记册，该登记册载有该国所有定罪的详细信息。中度（HR=2.47，CI=2.34-2.60）和高水平（HR=3.43，CI=3.25-3.63）的母亲SDP与后代暴力信念的风险增加，即使在控制母亲和父亲的特征。然而，当比较不同暴露的兄弟姐妹时，SDP和暴力信念之间没有关联（HR中度=1.02，CI=0.79-1.30; HR高=1.03，CI=0.78-1.37）。在整个人群中，SDP也与非暴力信念相关（HR中度=1.62，CI=1.58-1.66; HR高=1.87，CI=1.82-1.92），并控制协变量。但是，当比较差异暴露的兄弟姐妹时，没有相关性（HR中度=0.89，CI=0.78-1.01; HR高=0.89，CI=0.78-1.02）。结果表明，家庭背景因素占母亲SDP和刑事定罪之间的关联，而不是特定的接触SDP。
The association between maternal smoking during pregnancy (SDP) and offspring disruptive behaviors has been well documented, but it is unclear whether exposure to SDP or the effects of factors correlated with SDP account for the increased risk. To test whether the association between SDP and offspring criminal convictions was consistent with a causal connection or due to familial background factors by controlling for measured covariates and using a quasi-experimental approach. We used a population-based study of children born in Sweden from 1983–1989 (N=609,372) to examine the association between SDP and offspring criminal convictions, while controlling for measured traits of both parents. We also compared siblings differentially exposed to SDP (N=50,339) to account for unmeasured familial factors that could account for the association. Population-based study of all children born in Sweden from 1983–1989 with information on maternal SDP and offspring criminal convictions, based on national registries collected by the Swedish government. Violent and nonviolent convictions, based on the Swedish National Crime Register, a register with detailed information on all convictions in the country. Moderate (HR=2.47, CI=2.34–2.60) and high levels (HR=3.43, CI=3.25–3.63) of maternal SDP was associated with an increased risk for offspring violent convictions, even when controlling for maternal and paternal traits. There was no association between SDP and violent convictions, however, when comparing differentially exposed siblings (HRmoderate=1.02, CI=0.79–1.30; HRhigh=1.03, CI=0.78–1.37). SDP also was associated with nonviolent convictions in the entire population (HRmoderate=1.62, CI=1.58–1.66; HRhigh=1.87, CI=1.82–1.92) and when controlling for covariates. But, there was no association when comparing siblings who were differentially exposed (HRmoderate=0.89, CI=0.78–1.01; HRhigh=0.89, CI=0.78–1.02). The results suggest that familial background factors account for the association between maternal SDP and criminal convictions, not the specific exposure to SDP.
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DOI：
10.1111/1469-7610.00196
发表时间：
2003-11-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
D'Onofrio, BM;Turkheimer, EN;Emery, RE
通讯作者：
Emery, RE
影响因子：
5
作者：
Gilman, Stephen E.;Gardener, Hannah;Buka, Stephen L.
通讯作者：
Buka, Stephen L.
影响因子：
--
作者：
Fergusson, DM;Woodward, LJ;Horwood, LJ
通讯作者：
Horwood, LJ
影响因子：
6.9
作者：
Knopik, Valerie S.;Heath, Andrew C.;Martin, Nicholas G.
通讯作者：
Martin, Nicholas G.
影响因子：
12.7
作者：
Cnattingius, S;Haglund, B
通讯作者：
Haglund, B