Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
复制标题
补体因子 H Val62Ile 变异与年龄相关性黄斑变性的风险：一项荟萃分析
作者：
Yuan, Donglan;Yuan, Songtao;Xie, Ping;Liu, Qinghuai
目的探讨补体因子H (CFH) Val62Ile多态性与年龄相关性黄斑变性（AMD）易感性的确切关系。方法采用PubMed、EMBASE和Web of Science等数据库进行meta分析，查找相关研究。使用固定效应和随机效应模型估计总结优势比（ORs）和95%置信区间（ci）。不一致性指数（I2）用于评估异质性。采用漏斗图和Egger检验评价发表偏倚。并进行敏感性分析。结果14项研究，包括4438名AMD患者和6099名对照，基于搜索标准纳入meta分析。在总体人群中，GA+GG基因型与纯合子基因型AA的合并OR1为2.28(95%可信区间（CI）： 1.48 ~ 3.52)， GA杂合子基因型与AA的合并OR2为1.58 (95% CI: 1.13 ~ 2.19)， GG纯合子基因型与AA的合并OR3为2.90 (95% CI: 1.95 ~ 4.30)， G等位基因与A的合并OR4为1.77 （95% CI: 1.43 ~ 2.21）。在亚洲人群中，我们的结果提供了大量证据，证明Val62Ile变异与AMD显著相关（OR4=1.85, 95% CI: 1.63-2.09）。然而，在高加索人群中，在所有情况下都没有发现Val62Ile与AMD的显著关联。结论：我们的分析提供了大量证据，表明Val62Ile变异与亚洲人群的AMD显著相关。然而，我们的研究结果表明，在高加索人群中，Val62Ile多态性与AMD之间没有联系。
Purpose To evaluate the precise association of complement factor H (CFH) Val62Ile polymorphism with age-related macular degeneration (AMD) susceptibility. Methods We performed a meta-analysis using databases including PubMed, EMBASE, and Web of Science to find relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effect and random-effects models. The inconsistency index (I2) was used to assess heterogeneity. Funnel plots and Egger’s test were used to evaluate publication bias. Sensitivity analysis was also performed. Results Fourteen studies including 4,438 patients with AMD and 6,099 controls based on the search criteria were involved in the meta-analysis. In overall populations, the pooled OR1 for genotype GA+GG versus homozygous genotype AA was 2.28 (95% confidence interval (CI): 1.48–3.52), the OR2 of heterozygous genotype GA versus AA was 1.58 (95% CI: 1.13–2.19), the OR3 of homozygous genotype GG versus AA was 2.90 (95% CI: 1.95–4.30), and the OR4 of allele G versus A was 1.77 (95% CI: 1.43–2.21). In Asian populations, our results provided substantial evidence that the Val62Ile variant was significantly associated with AMD (OR4=1.85, 95% CI: 1.63–2.09). However, in Caucasian populations, no significant association of Val62Ile with AMD was established in all circumstances. Conclusions Our analysis provides substantial evidence that the Val62Ile variant is significantly associated with AMD in Asian populations. However, our results have demonstrated no link between the Val62Ile polymorphism and AMD in Caucasian populations.
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影响因子：
4.2
作者：
Sobrin, Lucia;Reynolds, Robyn;Yu, Yi;Fagerness, Jesen;Leveziel, Nicolas;Bernstein, Paul S.;Souied, Eric H.;Daly, Mark J.;Seddon, Johanna M.
通讯作者：
Seddon, Johanna M.
影响因子：
--
作者：
F. Ferris;M. Davis;T. Clemons;Li-Yin Lee;E. Chew;A. Lindblad;R. Milton;S. Bressler;R. Klein-R.-Klei
通讯作者：
F. Ferris;M. Davis;T. Clemons;Li-Yin Lee;E. Chew;A. Lindblad;R. Milton;S. Bressler;R. Klein-R.-Klei
影响因子：
--
作者：
A. Ramé
通讯作者：
A. Ramé
影响因子：
3.7
作者：
Ioannidis JP;Patsopoulos NA;Evangelou E
通讯作者：
Evangelou E
DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R