The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic.
The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic.
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大脑大脑：在Covid-19大流行期间未感染个体的神经炎症。
DOI：
10.1016/j.bbi.2022.02.018
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Loggia ML
中科院分区：
文献类型：
--
作者：
Brusaferri L;Alshelh Z;Martins D;Kim M;Weerasekera A;Housman H;Morrissey EJ;Knight PC;Castro-Blanco KA;Albrecht DS;Tseng CE;Zürcher NR;Ratai EM;Akeju O;Makary MM;Catana C;Mercaldo ND;Hadjikhani N;Veronese M;Turkheimer F;Rosen BR;Hooker JM;Loggia ML
虽然COVID-19研究在文献中出现了爆炸性增长，但与流行病相关的社会和生活方式中断对未感染者大脑健康的影响仍然没有得到充分研究。然而，全球范围内疲劳、脑雾、抑郁和其他类似“疾病行为”的症状的流行率增加，暗示即使在从未感染过病毒的人中，神经免疫机制也可能失调。我们比较了57个“大流行前”和15个“大流行”数据集，这些数据集来自最初作为对照受试者登记的个人，用于我们记录中的各种已完成或正在进行的研究，并证实SARS-CoV-2抗体检测呈阴性。我们使用了多模式分子脑成像（同步正电子发射断层扫描/磁共振波谱），行为测量，成像转录组学和血清检测的组合，以揭示流行病相关的压力源和神经炎症之间的联系。在2020年实施封锁/呆在家里措施后进行检查的健康个体显示，与封锁前的受试者相比，两种独立的神经炎症标志物（18 kDa转运蛋白、TSPO和肌醇）的大脑水平升高。两种炎症标志物（白细胞介素-16和单核细胞趋化蛋白-1）的血清水平也升高，尽管这些影响在校正多重比较后没有达到统计学显著性。与那些报告很少/没有症状的受试者相比，支持较高症状负担的受试者在海马（情绪改变、精神疲劳）、顶内沟和楔前叶（身体疲劳）中显示出较高的TSPO信号。锁定后TSPO信号变化与参与免疫/神经免疫功能的几个基因的组成型表达在空间上一致。这项研究表明，神经免疫激活可能是COVID-19大流行期间许多人经历的非病毒介导症状的潜在机制。未来的研究将需要证实和进一步解释这些初步发现。
While COVID-19 research has seen an explosion in the literature, the impact of pandemic-related societal and lifestyle disruptions on brain health among the uninfected remains underexplored. However, a global increase in the prevalence of fatigue, brain fog, depression and other “sickness behavior”-like symptoms implicates a possible dysregulation in neuroimmune mechanisms even among those never infected by the virus. We compared fifty-seven ‘Pre-Pandemic’ and fifteen ‘Pandemic’ datasets from individuals originally enrolled as control subjects for various completed, or ongoing, research studies available in our records, with a confirmed negative test for SARS-CoV-2 antibodies. We used a combination of multimodal molecular brain imaging (simultaneous positron emission tomography / magnetic resonance spectroscopy), behavioral measurements, imaging transcriptomics and serum testing to uncover links between pandemic-related stressors and neuroinflammation. Healthy individuals examined after the enforcement of 2020 lockdown/stay-at-home measures demonstrated elevated brain levels of two independent neuroinflammatory markers (the 18 kDa translocator protein, TSPO, and myoinositol) compared to pre-lockdown subjects. The serum levels of two inflammatory markers (interleukin-16 and monocyte chemoattractant protein-1) were also elevated, although these effects did not reach statistical significance after correcting for multiple comparisons. Subjects endorsing higher symptom burden showed higher TSPO signal in the hippocampus (mood alteration, mental fatigue), intraparietal sulcus and precuneus (physical fatigue), compared to those reporting little/no symptoms. Post-lockdown TSPO signal changes were spatially aligned with the constitutive expression of several genes involved in immune/neuroimmune functions. This work implicates neuroimmune activation as a possible mechanism underlying the non-virally-mediated symptoms experienced by many during the COVID-19 pandemic. Future studies will be needed to corroborate and further interpret these preliminary findings.
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影响因子：
4.2
作者：
Hridi SU;Barbour M;Wilson C;Franssen AJ;Harte T;Bushell TJ;Jiang HR
通讯作者：
Jiang HR
DOI：
10.1016/j.bbi.2018.09.018
发表时间：
2019-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Albrecht DS;Forsberg A;Sandström A;Bergan C;Kadetoff D;Protsenko E;Lampa J;Lee YC;Höglund CO;Catana C;Cervenka S;Akeju O;Lekander M;Cohen G;Halldin C;Taylor N;Kim M;Hooker JM;Edwards RR;Napadow V;Kosek E;Loggia ML
通讯作者：
Loggia ML
易位蛋白 18 kDa 激动剂可预防脑缺血/再灌注损伤
影响因子：
9.3
作者：
Li HD;Li M;Shi E;Jin WN;Wood K;Gonzales R;Liu Q
通讯作者：
Liu Q
影响因子：
11
作者：
DiSabato DJ;Nemeth DP;Liu X;Witcher KG;O'Neil SM;Oliver B;Bray CE;Sheridan JF;Godbout JP;Quan N
通讯作者：
Quan N
影响因子：
2.1
作者：
Airas L;Rissanen E;Rinne JO
通讯作者：
Rinne JO