A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort.
A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort.
复制标题
独立协作队列中血管认知障碍遗传学荟萃分析结果的验证研究。
DOI：
--
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
P. Kehoe
中科院分区：
文献类型：
--
作者：
O. Skrobot;A. McKnight;P. Passmore;D. Seripa;P. Mecocci;F. Panza;R. Kalaria;G. Wilcock;M. Munafo;T. Erkinjuntti;P. Karhunen;T. Pessi;M. Martiskainen;S. Love;P. Kehoe
血管性认知障碍（VCI），包括其严重形式，血管性痴呆（VaD），是第二种最常见的痴呆形式。散发性VCI的遗传病因在很大程度上仍然未知。我们之前对2012年7月6日之前发表的所有散发性VCI的遗传关联研究进行了系统回顾和荟萃分析，结果表明APOE（APOE 4，APOE 2）和MTHFR（rs1801133）变异与VCI的易感性相关。在一个新的独立的相对较大的合作欧洲队列VaD（nmax = 549）和老年非痴呆症样本（nmax = 552）进行从头基因分型。 在可用的情况下，来自Illumina的610-quad阵列的1210个GERAD 1对照样品的基因型数据也包括在所检查的基因的分析中。使用Cochran-Armitage趋势检验检验相关性：MTHFR rs1801133（OR = 1.36，95%CI 1.16 - 1.58，p =<0.0001），APOE rs7412（OR = 0.62，95%CI 0.42 - 0.90，p = 0.01）和APOE rs429358（OR = 1.59，95%CI 1.17 - 2.16，p = 0.003）。 还观察到与APOE等位基因的关联; APOE等位基因：APOE 4（OR = 1.85，95% CI 1.35 - 2.52，p =<0.0001）和APOE等位基因：APOE 2（OR = 0.67，95% CI 0.46 - 0.98，p = 0.03）。 Logistic回归和Bonferroni校正校正的性别，年龄和人口的队列亚组中保持APOE rs429358和APOE rs429358等位基因的关联。
Vascular cognitive impairment (VCI), including its severe form, vascular dementia (VaD), is the second most common form of dementia. The genetic etiology of sporadic VCI remains largely unknown. We previously conducted a systematic review and meta-analysis of all published genetic association studies of sporadic VCI prior to 6 July 2012, which demonstrated that APOE (ɛ4, ɛ2) and MTHFR (rs1801133) variants were associated with susceptibility for VCI. De novo genotyping was conducted in a new independent relatively large collaborative European cohort of VaD (nmax = 549) and elderly non-demented samples (nmax = 552). Where available, genotype data derived from Illumina's 610-quad array for 1210 GERAD1 control samples were also included in analyses of genes examined. Associations were tested using the Cochran-Armitage trend test: MTHFR rs1801133 (OR = 1.36, 95% CI 1.16-1.58, p = <0.0001), APOE rs7412 (OR = 0.62, 95% CI 0.42-0.90, p = 0.01), and APOE rs429358 (OR = 1.59, 95% CI 1.17-2.16, p = 0.003). Association was also observed with APOE epsilon alleles; ɛ4 (OR = 1.85, 95% CI 1.35-2.52, p = <0.0001) and ɛ2 (OR = 0.67, 95% CI 0.46-0.98, p = 0.03). Logistic regression and Bonferroni correction in a subgroup of the cohort adjusted for gender, age, and population maintained the association of APOE rs429358 and ɛ4 allele.
登录
查看更多内容
影响因子：
5
作者：
Elkins, Jacob S.;Johnston, S. Claiborne;Yaffe, Kristine
通讯作者：
Yaffe, Kristine
DOI：
10.3233/jad-2011-110824
发表时间：
2012
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Gerrish A;Russo G;Richards A;Moskvina V;Ivanov D;Harold D;Sims R;Abraham R;Hollingworth P;Chapman J;Hamshere M;Pahwa JS;Dowzell K;Williams A;Jones N;Thomas C;Stretton A;Morgan AR;Lovestone S;Powell J;Proitsi P;Lupton MK;Brayne C;Rubinsztein DC;Gill M;Lawlor B;Lynch A;Morgan K;Brown KS;Passmore PA;Craig D;McGuinness B;Todd S;Johnston JA;Holmes C;Mann D;Smith AD;Love S;Kehoe PG;Hardy J;Mead S;Fox N;Rossor M;Collinge J;Maier W;Jessen F;Kölsch H;Heun R;Schürmann B;van den Bussche H;Heuser I;Kornhuber J;Wiltfang J;Dichgans M;Frölich L;Hampel H;Hüll M;Rujescu D;Goate AM;Kauwe JS;Cruchaga C;Nowotny P;Morris JC;Mayo K;Livingston G;Bass NJ;Gurling H;McQuillin A;Gwilliam R;Deloukas P;Davies G;Harris SE;Starr JM;Deary IJ;Al-Chalabi A;Shaw CE;Tsolaki M;Singleton AB;Guerreiro R;Mühleisen TW;Nöthen MM;Moebus S;Jöckel KH;Klopp N;Wichmann HE;Carrasquillo MM;Pankratz VS;Younkin SG;Jones L;Holmans PA;O'Donovan MC;Owen MJ;Williams J
通讯作者：
Williams J
影响因子：
14.5
作者：
Verhoeven, Kristien;Claeys, Kristl G.;Timmerman, Vincent
通讯作者：
Timmerman, Vincent
影响因子：
7.4
作者：
Gan, Xueqi;Wu, Long;Huang, Shengbin;Zhong, Changjia;Shi, Honglian;Li, Guangyue;Yu, Haiyang;Swerdlow, Russell Howard;Chen, John Xi;Yan, Shirley ShiDu
通讯作者：
Yan, Shirley ShiDu
DOI：
10.1093/gerona/gls187
发表时间：
2013-04-01
影响因子：
5.1
作者：
Koyama, Alain;O'Brien, Jacqueline;Yaffe, Kristine
通讯作者：
Yaffe, Kristine