Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis.

Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis.
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纳米医学在前列腺癌骨转移诊断和治疗中的研究进展。

DOI:
10.3390/molecules26020384
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发表时间:
2021-01-13
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Melancon MP
Melancon MP
中科院分区:
其他
文献类型:
--
作者:
Hagaman DE;Damasco JA;Perez JVD;Rojo RD;Melancon MP

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晚期前列腺癌患者可能发生疼痛和使人衰弱的骨转移。目前可用于前列腺癌骨转移的干预措施,包括化疗、双膦酸盐和放射性药物,仅是姑息性的。它们可以缓解疼痛,减少并发症(例如,骨折),并提高生活质量,但它们并没有显著提高生存时间。因此,需要额外的策略来提高前列腺癌骨转移的诊断和治疗。纳米技术是一种多功能平台,已用于提高前列腺癌骨转移各种治疗的特异性和治疗效果。在这篇综述中,我们总结了临床前研究,利用纳米技术开发新的诊断成像工具,翻译模型和治疗方法,以打击前列腺癌骨转移。
Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases.
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