Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
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DOI：
10.1021/ja908117a
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发表时间：
2010-04-07
影响因子：
15
通讯作者：
Wheate, Nial J.
中科院分区：
文献类型：
--
作者：
Brown, Sarah D.;Nativo, Paola;Smith, Jo-Ann;Stirling, David;Edwards, Paul R.;Venugopal, Balaji;Flint, David J.;Plumb, Jane A.;Graham, Duncan;Wheate, Nial J.
基于铂的抗癌药物顺铂、卡铂和奥沙利铂是化疗的重要组成部分，但受到严重的剂量限制性副作用以及肿瘤快速产生耐药性的能力的限制。通过使用能够被动或主动靶向癌症的药物递送载体，可以对这些药物进行改进。在这项研究中，我们将抗癌药物奥沙利铂的活性成分连接到金纳米粒子上，以改进药物递送。裸金纳米粒子通过带有羧酸盐基团封端的巯基化聚乙二醇（PEG）单分子层进行功能化。将[Pt(1R,2R - 二氨基环己烷)(H₂O)₂]₂NO₃添加到PEG表面，每个纳米粒子产生一种含有280（±20）个药物分子的超分子复合物。对连接铂的纳米粒子在A549肺上皮癌细胞系以及结肠癌细胞系HCT116、HCT15、HT29和RKO中的细胞毒性、药物摄取和定位进行了检测。在所有细胞系中，连接铂的纳米粒子表现出与单独使用奥沙利铂相当或明显更好的细胞毒性，并且在肺癌细胞中具有穿透细胞核的特殊能力。
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of drug-delivery vehicles that are able to target cancers passively or actively. In this study, we have tethered the active component of the anticancer drug oxaliplatin to a gold nanoparticle for improved drug delivery. Naked gold nanoparticles were functionalized with a thiolated poly(ethylene glycol) (PEG) monolayer capped with a carboxylate group. [Pt(1R,2R-diaminocyclohexane)(H2O)2]2NO3 was added to the PEG surface to yield a supramolecular complex with 280 (±20) drug molecules per nanoparticle. The platinum-tethered nanoparticles were examined for cytotoxicity, drug uptake, and localization in the A549 lung epithelial cancer cell line and the colon cancer cell lines HCT116, HCT15, HT29, and RKO. The platinum-tethered nanoparticles demonstrated as good as, or significantly better, cytotoxicity than oxaliplatin alone in all of the cell lines and an unusual ability to penetrate the nucleus in the lung cancer cells.
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影响因子：
7.4
作者：
GRABAR, KC;FREEMAN, RG;NATAN, MJ
通讯作者：
NATAN, MJ
DOI：
10.1073/pnas.0504274102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Dharap, SS;Wang, Y;Minko, T
通讯作者：
Minko, T
影响因子：
14.9
作者：
Li, Z;Jin, RC;Letsinger, RL
通讯作者：
Letsinger, RL
影响因子：
17.1
作者：
Eck, Wolfgang;Craig, Gary;Mason, Michael D.
通讯作者：
Mason, Michael D.
影响因子：
4.4
作者：
Howell, B. A.;Fan, D.;Rakesh, Leela
通讯作者：
Rakesh, Leela