Advances in profiling chromatin architecture shed light on the regulatory dynamics underlying brain disorders.
Advances in profiling chromatin architecture shed light on the regulatory dynamics underlying brain disorders.
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分析染色质体系结构的进步揭示了脑部疾病的调节动力学。
DOI：
10.1016/j.semcdb.2021.08.013
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发表时间：
2022-01
影响因子：
7.3
通讯作者：
Won H
中科院分区：
文献类型：
--
作者：
Pratt BM;Won H
Understanding the exquisitely complex nature of the three-dimensional organization of the genome and how it affects gene regulation remains a central question in biology. Recent advances in sequencing- and imaging-based approaches in decoding the three-dimensional chromatin landscape have enabled a systematic characterization of gene regulatory architecture. In this review, we outline how chromatin architecture provides a reference atlas to predict the functional consequences of non-coding variants associated with human traits and disease. High-throughput perturbation assays such as massively parallel reporter assays (MPRA) and CRISPR-based genome engineering in combination with a reference atlas opened an avenue for going beyond observational studies to experimentally validating the regulatory principles of the genome. We conclude by providing a suggested path forward by calling attention to barriers that can be addressed for a more complete understanding of the regulatory landscape of the human brain.
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影响因子：
6
作者：
Crowley C;Yang Y;Qiu Y;Hu B;Abnousi A;Lipiński J;Plewczyński D;Wu D;Won H;Ren B;Hu M;Li Y
通讯作者：
Li Y
DOI：
10.1038/nrg3454
发表时间：
2013-06
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
48
作者：
Fiorillo L;Musella F;Conte M;Kempfer R;Chiariello AM;Bianco S;Kukalev A;Irastorza-Azcarate I;Esposito A;Abraham A;Prisco A;Pombo A;Nicodemi M
通讯作者：
Nicodemi M
影响因子：
64.8
作者：
Beagrie RA;Scialdone A;Schueler M;Kraemer DC;Chotalia M;Xie SQ;Barbieri M;de Santiago I;Lavitas LM;Branco MR;Fraser J;Dostie J;Game L;Dillon N;Edwards PA;Nicodemi M;Pombo A
通讯作者：
Pombo A
影响因子：
25
作者：
Beagan JA;Pastuzyn ED;Fernandez LR;Guo MH;Feng K;Titus KR;Chandrashekar H;Shepherd JD;Phillips-Cremins JE
通讯作者：
Phillips-Cremins JE