Associations of prior concussion severity with brain microstructure using mean apparent propagator magnetic resonance imaging.
Associations of prior concussion severity with brain microstructure using mean apparent propagator magnetic resonance imaging.
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DOI：
10.1002/hbm.26556
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发表时间：
2024-01
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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磁共振成像（MRI）扩散研究显示，有脑震荡病史的运动员存在慢性显微结构组织异常，但结果不一致。脑震荡合并创伤后遗忘症（PTA）和/或意识丧失（LOC）与更大的生理损伤有关。与传统的弥散张量成像相比，新的平均表观传播体（MAP） MRI有望对此类组织损伤更敏感。本研究用MAP‐MRI检查了先前脑震荡严重程度对微结构的影响。大学年龄运动员（N = 111, 38名女性；最近一次脑震荡发生后≥6个月，如果有的话）完成了半结构化访谈，以确定是否存在先前的脑震荡和相关损伤特征，包括PTA和LOC。从多壳扩散数据中计算MAP - MRI指标（平均非高斯扩散[NG mean]、回归原点概率[RTOP]和均方位移[MSD]），然后通过一级模型（有/没有先前脑震荡的运动员）和两个二级模型（有/没有先前脑震荡的运动员有PTA和/或LOC，有/没有先前脑震荡的运动员只有LOC）的组比较，评估其与脑震荡严重程度的关系。贝叶斯多层模型分别估计了白质和皮层下灰质感兴趣区域（ROI）的模型。在灰质中，初级模型显示双侧白质的NG Mean和RTOP降低，左壳核的NG Mean降低。在白质中，所有ROI模型中，先前脑震荡的NG均值较低，LOC进一步降低。然而，只有先前的脑震荡伴LOC与RTOP降低和MSD增加有关。分别在男性和女性运动员中进行的探索性分析表明，主要模型中的关联可能因性别而异。结果表明，灰质的微观结构测量与脑震荡的一般病史有关，而白质中可能存在严重依赖于先前脑震荡的关联。平均视传播因子-磁共振成像（MAP - MRI）对与先前脑震荡病史相关的扩散差异敏感。在白质中观察到先前脑震荡的严重程度依赖于MAP - MRI指标的广泛差异。先前脑震荡的一般病史与灰质MAP - MRI指标的局部差异有关。
Magnetic resonance imaging (MRI) diffusion studies have shown chronic microstructural tissue abnormalities in athletes with history of concussion, but with inconsistent findings. Concussions with post‐traumatic amnesia (PTA) and/or loss of consciousness (LOC) have been connected to greater physiological injury. The novel mean apparent propagator (MAP) MRI is expected to be more sensitive to such tissue injury than the conventional diffusion tensor imaging. This study examined effects of prior concussion severity on microstructure with MAP‐MRI. Collegiate‐aged athletes (N = 111, 38 females; ≥6 months since most recent concussion, if present) completed semistructured interviews to determine the presence of prior concussion and associated injury characteristics, including PTA and LOC. MAP‐MRI metrics (mean non‐Gaussian diffusion [NG Mean], return‐to‐origin probability [RTOP], and mean square displacement [MSD]) were calculated from multi‐shell diffusion data, then evaluated for associations with concussion severity through group comparisons in a primary model (athletes with/without prior concussion) and two secondary models (athletes with/without prior concussion with PTA and/or LOC, and athletes with/without prior concussion with LOC only). Bayesian multilevel modeling estimated models in regions of interest (ROI) in white matter and subcortical gray matter, separately. In gray matter, the primary model showed decreased NG Mean and RTOP in the bilateral pallidum and decreased NG Mean in the left putamen with prior concussion. In white matter, lower NG Mean with prior concussion was present in all ROI across all models and was further decreased with LOC. However, only prior concussion with LOC was associated with decreased RTOP and increased MSD across ROI. Exploratory analyses conducted separately in male and female athletes indicate associations in the primary model may differ by sex. Results suggest microstructural measures in gray matter are associated with a general history of concussion, while a severity‐dependent association of prior concussion may exist in white matter. Mean apparent propagator‐magnetic resonance imaging (MAP‐MRI) is sensitive to diffusion differences associated with history of prior concussion. A severity‐dependent association of prior concussion with widespread differences in MAP‐MRI metrics was observed in white matter. A general history of prior concussion is associated with localized differences in MAP‐MRI metrics in gray matter.
影响因子：
4.3
作者：
Qiu, Yage;Li, Qingshang;Wu, Dongmei;Zhang, Yiming;Cheng, Jiahui;Cao, Zhijun;Zhou, Yan
通讯作者：
Zhou, Yan