Philippine Ayta possess the highest level of Denisovan ancestry in the world.
Philippine Ayta possess the highest level of Denisovan ancestry in the world.
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DOI：
10.1016/j.cub.2021.07.022
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发表时间：
2021-10-11
期刊：
影响因子：
--
通讯作者：
Jakobsson M
中科院分区：
文献类型：
--
作者：
Larena M;McKenna J;Sanchez-Quinto F;Bernhardsson C;Ebeo C;Reyes R;Casel O;Huang JY;Hagada KP;Guilay D;Reyes J;Allian FP;Mori V;Azarcon LS;Manera A;Terando C;Jamero L Jr;Sireg G;Manginsay-Tremedal R;Labos MS;Vilar RD;Latiph A;Saway RL;Marte E;Magbanua P;Morales A;Java I;Reveche R;Barrios B;Burton E;Salon JC;Kels MJT;Albano A;Cruz-Angeles RB;Molanida E;Granehäll L;Vicente M;Edlund H;Loo JH;Trejaut J;Ho SYW;Reid L;Lambeck K;Malmström H;Schlebusch C;Endicott P;Jakobsson M
多种证据表明现代人与古代丹尼索瓦人杂交。在这里，我们报告了澳大利亚人和丹尼索瓦人在东南亚岛屿之间的共同人口历史。我们的分析基于来自菲律宾118个民族的1230万个基因型，包括25个不同的自我认同的内格里托人群，沿着高覆盖率的南方古猿和Ayta Magbukon Negritos的基因组。我们发现，Ayta Magbukon拥有世界上最高水平的Denisovan血统--比澳大利亚人和巴布亚人高出30%-40%，这与Denisovans的独立混合事件相一致。加上最近描述的人luzonensis，我们认为，有多个古老的物种，居住在菲律宾之前，现代人类的到来，这些古老的群体可能已经遗传相关。总而言之，我们的研究结果揭示了亚太地区现代人和古代人复杂交织的历史，在那里，不同的岛民丹尼索瓦人人口在多个地点和不同的时间点与新来的澳大拉西亚人不同地混合。综合分析118个菲律宾族群的古老祖先Ayta Magbukon显示，Denisovan人的祖先比Australopapuans人大30%-40%。揭示了菲律宾Ayta拥有世界上最高水平的Denisovan血统-比Australopapuans高出30%-40%-与Denisovans到Negritos的独立混合事件一致。因此，在现代人类到来之前，菲律宾群岛可能居住着多个古老的群体。
Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world—∼30%–40% greater than that of Australians and Papuans—consistent with an independent admixture event into Negritos from Denisovans. Together with the recently described Homo luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related. Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time. Comprehensive analyses of archaic ancestry among 118 Philippine ethnic groups Ayta Magbukon display ∼30%–40% greater Denisovan ancestry than Australopapuans The model is explained by a distinct admixture event into Negritos from Denisovans Prior to modern humans, Islander Denisovans may have been present in the Philippines Larena et al. reveal Philippine Ayta to possess the highest level of Denisovan ancestry in the world—∼30%–40% greater than that of Australopapuans—consistent with an independent admixture event into Negritos from Denisovans. The Philippine archipelago is thus likely inhabited by multiple archaic groups prior to the arrival of modern humans.
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来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.3
作者：
Aghakhanian F;Yunus Y;Naidu R;Jinam T;Manica A;Hoh BP;Phipps ME
通讯作者：
Phipps ME
影响因子：
5.8
作者：
Behr, Aaron A.;Liu, Katherine Z.;Ramachandran, Sohini
通讯作者：
Ramachandran, Sohini
影响因子：
2.2
作者：
Dennell, Robin;Martinon-Torres, Maria;Xing, Gao
通讯作者：
Xing, Gao
影响因子：
3.2
作者：
Ao, Hong;Liu, Chun-Ru;Xu, Xinwen
通讯作者：
Xu, Xinwen