Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia.
Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia.
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DOI：
10.1093/gbe/evv065
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发表时间：
2015-04-14
影响因子：
3.3
通讯作者：
Phipps ME
中科院分区：
文献类型：
--
作者：
Aghakhanian F;Yunus Y;Naidu R;Jinam T;Manica A;Hoh BP;Phipps ME
马来西亚的土著居民被称为奥兰阿斯利（OA）显示出巨大的形态，人类学和语言的多样性。然而，这些种群的遗传历史仍然不清楚。我们对黑格里托人、塞诺伊人和原始马来人三个主要群体进行了超过200万个单核苷酸多态性的高密度阵列基因分型。结构分析表明，尽管所有OA群体在遗传上与东亚（EA）群体最接近，但它们在本质上是不同的。我们确定了安达曼人和马来西亚黑人之间的遗传亲缘关系，这可能表明这两个群体之间存在古老的联系。我们还发现，Senoi和原始马来人可能是黑格里托人和EA人之间的混种。正式的混合测试提供了说austrasian - asian的OAs与来自东南亚（SEA）和华南的人群之间基因流动的证据，这表明这些人在南岛人扩张之前在东南亚广泛存在。在oa中发现的高连锁不平衡（LD）和高纯合性反映了隔离和瓶颈。根据Ne和LD估计，这些种群在晚更新世（14.5 ~ 8 KYA）从东亚分化而来。从黑格里托人到塞诺伊人，再到原始马来人的连续分化时间，结合祖先的标记，提供了从第一次走出非洲开始的多波向东南亚迁移的证据，随后是早期火车和随后的南岛人扩张。
Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history of these populations remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups of Negrito, Senoi, and Proto-Malay. Structural analyses indicated that although all OA groups are genetically closest to East Asian (EA) populations, they are substantially distinct. We identified a genetic affinity between Andamanese and Malaysian Negritos which may suggest an ancient link between these two groups. We also showed that Senoi and Proto-Malay may be admixtures between Negrito and EA populations. Formal admixture tests provided evidence of gene flow between Austro-Asiatic-speaking OAs and populations from Southeast Asia (SEA) and South China which suggest a widespread presence of these people in SEA before Austronesian expansion. Elevated linkage disequilibrium (LD) and enriched homozygosity found in OAs reflect isolation and bottlenecks experienced. Estimates based on Ne and LD indicated that these populations diverged from East Asians during the late Pleistocene (14.5 to 8 KYA). The continuum in divergence time from Negritos to Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions.
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影响因子：
4.5
作者：
Petersen DC;Libiger O;Tindall EA;Hardie RA;Hannick LI;Glashoff RH;Mukerji M;Indian Genome Variation Consortium;Fernandez P;Haacke W;Schork NJ;Hayes VM
通讯作者：
Hayes VM
DOI：
10.1073/pnas.1211927110
发表时间：
2013-01-29
影响因子：
11.1
作者：
Pugach, Irina;Delfin, Frederick;Stoneking, Mark
通讯作者：
Stoneking, Mark
影响因子：
10.7
作者：
Hill, Catherine;Soares, Pedro;Richards, Martin
通讯作者：
Richards, Martin
影响因子：
56.9
作者：
Abdulla, Mahmood Ameen;Ahmed, Ikhlak;Zilfalil, Bin Alwi
通讯作者：
Zilfalil, Bin Alwi
影响因子：
7
作者：
McEvoy, Brian P.;Powell, Joseph E.;Visscher, Peter M.
通讯作者：
Visscher, Peter M.