Effect of Salt Intervention on Serum Levels of Fibroblast Growth Factor 23 (FGF23) in Chinese Adults: An Intervention Study.
Effect of Salt Intervention on Serum Levels of Fibroblast Growth Factor 23 (FGF23) in Chinese Adults: An Intervention Study.
复制标题
盐干预对中国成人成纤维细胞生长因子 23 (FGF23) 血清水平的影响：一项干预研究
DOI：
10.12659/msm.906489
复制
发表时间：
2018-04-02
期刊：
影响因子：
--
通讯作者：
Mu JJ
中科院分区：
文献类型：
--
作者：
Hu JW;Wang Y;Chu C;Mu JJ
Background Fibroblast growth factor 23 (FGF23), a prominent regulator of phosphate and calcium metabolism, regulates sodium excretion in distal tubules through sodium-chloride cotransporter. This effect regulates blood pressure. Salt intake exerts effects on serum levels of FGF23 in mice. The aim of this study was to explore whether salt intervention affects serum concentrations of FGF23 in Chinese adults. Material/Methods We enrolled 44 participants from Lantian, a rural community of Shaanxi, China. All participants were maintained on a three-day normal diet, which was sequentially followed by a seven-day low-Na+ diet and seven-day high-Na+ diet. Serum FGF23 concentrations were assessed by ELISA. Results Serum FGF23 concentrations elevated during low-salt diet compared with levels at baseline (66.20±44.21 pg/mL versus 86.77±53.74 pg/mL, p<0.05) and remarkably decreased when changed from low to high salt intake (86.77±53.74 pg/mL versus 49.26±42.67 pg/mL, p<0.001). Responses of FGF23 to salt intervention were more prominent in normotensive, older than 60 years, BMI <24 kg/m2 and salt-resistant individuals. Furthermore, a significant inverse correlation was observed between 24-hour urinary sodium and serum concentrations of FGF23 after adjusting age, sex, BMI and hypertension status. Conclusions Dietary salt intervention significantly affects serum FGF23 in Chinese adults.
登录
查看更多内容
Dahl 盐敏感大鼠中盐诱导的上皮间质转变依赖于血压升高。
DOI：
10.1590/1414-431x20133554
发表时间：
2014-02
期刊：
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
影响因子：
--
作者：
Wang Y;Mu JJ;Liu FQ;Ren KY;Xiao HY;Yang Z;Yuan ZY
通讯作者：
Yuan ZY
影响因子：
2.8
作者：
Rotondi S;Pasquali M;Tartaglione L;Muci ML;Mandanici G;Leonangeli C;Sales S;Farcomeni A;Mazzaferro S
通讯作者：
Mazzaferro S
盐诱导的肾病脑反射激活肾素-血管紧张素系统并促进 CKD 进展
影响因子：
13.6
作者：
Cao, Wei;Li, Aiqing;Hou, Fan Fan
通讯作者：
Hou, Fan Fan
DOI：
10.1161/hypertensionaha.116.07709
发表时间：
2016-11
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Gao D;Zuo Z;Tian J;Ali Q;Lin Y;Lei H;Sun Z
通讯作者：
Sun Z
影响因子：
1.6
作者：
Humalda JK;Seiler-Muler S;Kwakernaak AJ;Vervloet MG;Navis G;Fliser D;Heine GH;de Borst MH
通讯作者：
de Borst MH