Epidemiology of chronic Pseudomonas aeruginosa infections in the airways of lung transplant recipients with cystic fibrosis.
Epidemiology of chronic Pseudomonas aeruginosa infections in the airways of lung transplant recipients with cystic fibrosis.
复制标题
囊性纤维化肺移植受者气道慢性铜绿假单胞菌感染的流行病学。
作者：
S. Walter;P. Gudowius;J. Boßhammer;U. Römling;H. Weissbrodt;W. Schürmann;H. Hardt;B. Tümmler
背景技术背景：肺移植后囊性纤维化患者气道铜绿假单胞菌定植的来源尚不明确。使用基于DNA的分型系统进行了一项研究，以调查肺移植受者是否获得了新的铜绿假单胞菌菌株或保留了移植前的菌株。方法：从1988年至1994年在汉诺威医学院接受肺移植的11例囊性纤维化患者中，分析了移植前后的74株铜绿假单胞菌。从宏观限制性内切酶片段模式相似性来评估74株铜绿假单胞菌的遗传相关性。结果：11例肺移植受者在移植前和移植后各有一个相同的铜绿假单胞菌克隆。11名患者中有4名患者的气道在术前被两种或三种不同的克隆定殖，但移植后6个月，仅可检测到一种克隆。结论：这些结果表明，在肺移植受体的气道中的铜绿假单胞菌群体在移植前后没有变化，并且假定铜绿假单胞菌慢性引流到肺同种异体移植物中是由鼻窦和气管中的细菌储库引起的。
BACKGROUND: The source of airway colonisation with Pseudomonas aeruginosa is not well defined in patients with cystic fibrosis after lung transplantation. Using a DNA-based typing system a study was undertaken to investigate whether lung transplant recipients acquired new strains of P aeruginosa or retained those they had before transplantation. METHODS: Seventy four P aeruginosa isolates taken before and after transplantation were analysed from 11 patients with cystic fibrosis who had undergone lung transplantation in the Medical School of Hannover between 1988 and 1994. The genetic relatedness of the 74 P aeruginosa strains was evaluated from macrorestriction fragment pattern similarity. RESULTS: Each of the 11 lung transplant recipients harboured one identical P aeruginosa clone before and after transplantation. The airways of four of the 11 patients were preoperatively colonised by two or three different clones, but six months after transplantation only one clone was detectable. CONCLUSIONS: These results show that there is no change in the P aeruginosa population in the airways of lung transplant recipients before and after transplantation and it is assumed that the chronic drainage of P aeruginosa into the lung allografts is caused by the bacterial reservoir in the paranasal sinuses and the trachea.
影响因子：
6.4
作者：
THORPE, JE;BAUGHMAN, RP;STANECK, JL
通讯作者：
STANECK, JL
洋葱假单胞菌感染在临床患者和囊性纤维化肺移植受者中的传播性。
DOI：
10.1056/nejm199410133311504
发表时间：
1994
期刊：
The New England journal of medicine
影响因子：
--
作者：
Steinbach,S;Sun,L;Jiang,RZ;Flume,P;Gilligan,P;Egan,TM;Goldstein,R
通讯作者：
Goldstein,R
接受心肺移植的囊性纤维化患者可受益于上颌窦吻合术和反复鼻窦灌洗。
影响因子：
0.9
作者：
Lewiston,N;King,V;Umetsu,D;Starnes,V;Marshall,S;Kramer,M;Theodore,J
通讯作者：
Theodore,J