Effects of various cardiovascular drugs on indices obtained with two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs.
Effects of various cardiovascular drugs on indices obtained with two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs.
复制标题
各种心血管药物对健康犬左心房二维斑点追踪超声心动图和时间-左心房面积曲线分析获得的指标的影响。
DOI：
10.2460/ajvr.76.8.702
复制
发表时间：
2015
影响因子：
1
通讯作者：
M. Takiguchi
中科院分区：
文献类型：
--
作者：
T. Osuga;Kensuke Nakamura;T. Morita;S. Lim;N. Yokoyama;K. Morishita;H. Ohta;M. Takiguchi
目的
评价多巴酚丁胺、艾司洛尔、米力农和苯肾上腺素对健康犬左心房相位功能的影响。
动物
9只健康的比格犬。
程序
在4个实验日中的每一天使用丙泊酚镇静后，对犬恒速输注多巴酚丁胺（5 μg/kg/min）、艾司洛尔（500 μg/kg/min）、米力农（25 μg/kg，IV推注，随后为0.5 μg/kg/min）或苯异黄酮（2 μg/kg/min）。实验日之间至少间隔14天。每种药物给予6只犬。在心血管药物给药前（基线）和给药后进行常规和2-D斑点追踪超声心动图，并推导出时间-左心房面积曲线，以计算左心房储血器、导管和增压泵功能（左心房相位功能）以及左心室收缩力和左心室收缩力的指数。
结果
与基线值相比，多巴酚丁胺给药后左心房储血器和增压泵功能、左心室收缩力和左心室舒张功能指标显著增加;艾司洛尔给药后左心房相位功能和左心室舒张功能指标变化不显著，左心室收缩力指标显著受损;米力农治疗后左房相位功能和左室舒张功能指标变化不明显，左室收缩功能指标明显增强;苯异丙肾上腺素治疗后左房相位功能和左室舒张功能指标无明显变化，而左室收缩功能指标明显受损。
结论和临床相关性
结果表明，健康犬给予多巴酚丁胺、艾司洛尔、米力农或苯丙氨酸后，左心房相位功能指数相当稳定，左心室功能指数没有平行变化。
OBJECTIVE
To evaluate the effects of dobutamine, esmolol, milrinone, and phenylephrine on left atrial phasic function of healthy dogs.
ANIMALS
9 healthy Beagles.
PROCEDURES
Following sedation with propofol on each of 4 experimental days, dogs were administered a constant rate infusion of dobutamine (5 μg/kg/min), esmolol (500 μg/kg/min), milrinone (25 μg/kg, IV bolus, followed by 0.5 μg/kg/min), or phenylephrine (2 μg/kg/min). There was at least a 14-day interval between experimental days. Each drug was administered to 6 dogs. Conventional and 2-D speckle tracking echocardiography were performed before (baseline) and after administration of the cardiovascular drug, and time-left atrial area curves were derived to calculate indices for left atrial reservoir, conduit, and booster pump functions (left atrial phasic function) and left ventricular contractility and lusitropy.
RESULTS
Compared with baseline values, indices for left atrial reservoir and booster pump functions and left ventricular contractility and lusitropy were significantly increased following dobutamine administration; indices for left atrial phasic function and left ventricular lusitropy were changed insignificantly, and indices for left ventricular contractility were significantly impaired following esmolol administration; indices for left atrial phasic function and left ventricular relaxation were changed insignificantly, and indices for left ventricular systolic function were significantly augmented following milrinone administration; and indices for left atrial phasic function and left ventricular lusitropy were changed insignificantly, and indices of ventricular contractility were significantly impaired following phenylephrine administration.
CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that, following administration of dobutamine, esmolol, milrinone, or phenylephrine to healthy dogs, left atrial phasic function indices were fairly stable and did not parallel changes in left ventricular function indices.
年龄对静息时和正性肌力刺激期间舒张左心室充盈以及急性全身性高血压的影响：有意识的比格犬的实验研究。
影响因子：
4.8
作者：
Vandenberg,BF;Kieso,RA;Fox-Eastham,K;Tomanek,RJ;Kerber,RE
通讯作者：
Kerber,RE
影响因子：
37.8
作者：
Barbier, P;Solomon, SB;Glantz, SA
通讯作者：
Glantz, SA
患有心力衰竭的清醒犬对 PDE 抑制剂（米力农）的脱敏机制。
DOI：
10.1152/ajpheart.1999.276.5.h1699
发表时间：
1999
期刊：
The American journal of physiology
影响因子：
--
作者：
Sato,N;Asai,K;Okumura,S;Takagi,G;Shannon,RP;Fujita-Yamaguchi,Y;Ishikawa,Y;Vatner,SF;Vatner,DE
通讯作者：
Vatner,DE