Intracranial spectral amplitude dynamics of perceptual suppression in fronto-insular, occipito-temporal, and primary visual cortex.
Intracranial spectral amplitude dynamics of perceptual suppression in fronto-insular, occipito-temporal, and primary visual cortex.
复制标题
DOI：
10.3389/fpsyg.2014.01545
复制
发表时间：
2014
影响因子：
3.8
通讯作者：
Lachaux JP
中科院分区：
文献类型：
--
作者：
Vidal JR;Perrone-Bertolotti M;Kahane P;Lachaux JP
如果有意识的感知需要跨活跃的远距离大脑网络的全局信息整合，那么有意识感知的丧失如何影响这些远距离网络中的神经处理？关于知觉抑制（PS）的开创性研究描述了猕猴大脑初级视觉皮层、丘脑和外侧前额叶皮层中特定的局部神经网络反应。然而，PS的神经效应很少被研究这些皮质之外的脑内记录，同时跨越遥远的大脑区域。在这里，我们结合了（1）一种新的实验范式，其中我们通过使用具有瞬时对比度变化的视觉适应来产生类似的感知消失和再现，以及（2）从人类颅内电极采样的宽脑区的电生理观察。我们专注于宽带高频（50-150 Hz，即，γ）和低频（8-24 Hz）与目标可见性和不可见性相关的神经活动幅度调制。我们报告说，低频振幅调制反映了刺激的可见性在一个更大的合奏记录网站相比，宽带伽马响应，在不同的大脑区域，包括枕叶，颞叶和额叶皮质。此外，宽带伽马响应的动力学区分刺激的可见性，刺激的不可见性早于前额叶和额下回，而不是在颞叶区域，这表明额岛皮质在自上而下的处理有意识的知觉可能发挥的作用。最后，我们报告说，在初级视觉皮层只有低频振幅调制直接相关的感知状态。有趣的是，在这个感觉区宽带伽马调制PS期间，但成为积极调制后300毫秒时，刺激再次呈现可见，这表明，本地网络可以点燃自上而下的影响，在有意识的感知。
If conscious perception requires global information integration across active distant brain networks, how does the loss of conscious perception affect neural processing in these distant networks? Pioneering studies on perceptual suppression (PS) described specific local neural network responses in primary visual cortex, thalamus and lateral prefrontal cortex of the macaque brain. Yet the neural effects of PS have rarely been studied with intracerebral recordings outside these cortices and simultaneously across distant brain areas. Here, we combined (1) a novel experimental paradigm in which we produced a similar perceptual disappearance and also re-appearance by using visual adaptation with transient contrast changes, with (2) electrophysiological observations from human intracranial electrodes sampling wide brain areas. We focused on broadband high-frequency (50–150 Hz, i.e., gamma) and low-frequency (8–24 Hz) neural activity amplitude modulations related to target visibility and invisibility. We report that low-frequency amplitude modulations reflected stimulus visibility in a larger ensemble of recording sites as compared to broadband gamma responses, across distinct brain regions including occipital, temporal and frontal cortices. Moreover, the dynamics of the broadband gamma response distinguished stimulus visibility from stimulus invisibility earlier in anterior insula and inferior frontal gyrus than in temporal regions, suggesting a possible role of fronto-insular cortices in top–down processing for conscious perception. Finally, we report that in primary visual cortex only low-frequency amplitude modulations correlated directly with perceptual status. Interestingly, in this sensory area broadband gamma was not modulated during PS but became positively modulated after 300 ms when stimuli were rendered visible again, suggesting that local networks could be ignited by top–down influences during conscious perception.
登录
查看更多内容
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
16.2
作者：
Gardner, JL;Sun, P;Cheng, K
通讯作者：
Cheng, K
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
DOI：
10.1364/josaa.1.000216
发表时间：
1984-01-01
影响因子：
1.9
作者：
BURBECK, CA;KELLY, DH
通讯作者：
KELLY, DH
影响因子：
3.1
作者：
Dalal, Sarang S.;Vidal, Juan R.;Jerbi, Karim
通讯作者：
Jerbi, Karim