Congenital heart disease affects cerebral size but not brain growth.
Congenital heart disease affects cerebral size but not brain growth.
复制标题
DOI：
10.1007/s00246-012-0269-9
复制
发表时间：
2012-10
影响因子：
1.6
通讯作者：
Beca, John
中科院分区：
文献类型：
--
作者：
Ortinau, Cynthia;Inder, Terrie;Lambeth, Jennifer;Wallendorf, Michael;Finucane, Kirsten;Beca, John
患有CHD的婴儿具有延迟的脑成熟和脑体积的改变。大脑指标是一种简单的测量技术，可用于评估大脑发育。这项研究使用大脑指标来检验这一假设，即大脑大小的改变在三个月大时持续存在，并且患有CHD的婴儿的大脑生长速度比对照组婴儿慢。对57例先天性心脏病患儿进行了系列脑磁共振成像（MRI）检查。为了评估出生后前三个月的脑生长，在术前和三个月大时进行MRI检查，对19个组织和液体空间进行脑测量。术前，CHD婴儿的额叶、顶叶、小脑和脑干测量值较小（p<0.001）。在三个月大的时候，除了小脑之外，所有的测量结果都发生了变化。对照组和CHD组婴儿的脑发育无差异。然而，患有CHD的婴儿的小脑倾向于更大的生长。躯体发育是影响脑发育的主要因素。术前和术后局灶性白色病变的存在与脑大小或生长的改变无关。虽然患有CHD的婴儿在三个月大时大脑大小持续改变，但大脑生长速度与健康足月婴儿相似。躯体生长是大脑生长的主要预测因素，强调了在这一人群中最佳体重增加的重要性。
Infants with CHD have delayed brain maturation and alterations in brain volume. Brain metrics is a simple measurement technique that can be used to evaluate brain growth. This study used brain metrics to test the hypothesis that alterations in brain size persist at three months of age and that infants with CHD have slower rates of brain growth than control infants. Fifty-seven infants with CHD underwent serial brain magnetic resonance imaging (MRI). To evaluate brain growth across the first three months of life, brain metrics were undertaken on 19 tissue and fluid spaces on MRIs performed pre-operatively and at three months of age. Pre-operatively, infants with CHD have smaller frontal, parietal, cerebellar and brainstem measures (p<0.001). At three months of age, alterations persisted in all measures except the cerebellum. There was no difference between control and CHD infants in brain growth. However, the cerebellum trended towards greater growth in infants with CHD. Somatic growth was the primary factor that related to brain growth. Presence of focal white matter lesions pre- and post-operatively did not relate to alterations in brain size or growth. Although infants with CHD have persistent alterations in brain size at three months of age, rates of brain growth are similar to that of healthy term infants. Somatic growth was the primary predictor of brain growth, emphasizing the importance of optimal weight gain in this population.
登录
查看更多内容
DOI：
10.3174/ajnr.a1309
发表时间：
2009-01
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Nguyen The Tich S;Anderson PJ;Shimony JS;Hunt RW;Doyle LW;Inder TE
通讯作者：
Inder TE
影响因子：
1
作者：
Bellinger, David C.;Newburger, Jane W.;Rappaport, Leonard A.
通讯作者：
Rappaport, Leonard A.
影响因子：
8
作者：
Ehrenkranz, RA;Dusick, AM;Poole, WK
通讯作者：
Poole, WK
影响因子：
1.4
作者：
Garel, C;Chantrel, E;Sebag, G
通讯作者：
Sebag, G
影响因子：
5.1
作者：
Inder, TE;Wells, SJ;Volpe, JJ
通讯作者：
Volpe, JJ