Assessment of reporting practices and reproducibility potential of a cohort of published studies in computational knee biomechanics.

Assessment of reporting practices and reproducibility potential of a cohort of published studies in computational knee biomechanics.
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DOI:
10.1002/jor.25358
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发表时间:
2023-02
影响因子:
2.8
通讯作者:
Erdemir, Ahmet
Erdemir, Ahmet
中科院分区:
医学3区
文献类型:
--
作者:
Halloran, Jason P.;Nohouji, Neda Abdollahi;Hafez, Mhd A.;Besier, Thor F.;Chokhandre, Snehal K.;Elmasry, Shady;Hume, Donald R.;Imhauser, Carl W.;Rooks, Nynke B.;Schneider, Marco T. Y.;Schwartz, Ariel;Shelburne, Kevin B.;Zaylor, William;Erdemir, Ahmet

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可重复性研究是科学方法的支柱,是科学进步的基础。然而,临床前科学的不可重复性估计在75%到90%之间。可重复性科学的重要性还没有在基于人体关节(如膝关节)的力学建模的背景下得到评估,尽管这是一个已经看到了显着增长的领域。在五个经验丰富的团队目前记录膝关节建模过程的背景下,本研究的目的是评估报告和研究中可重复性的感知潜力,这些团队认为这是对文献的重要贡献。通过投票选择了一组研究,结果是对九项研究进行评估,而不是对整个文献进行更广泛的分析。使用已发布的建模特征报告清单,队列被评估为“报告”及其“再现”的潜力,这被划分为六个主要的建模类别和三个子类别。Logistic回归分析显示,对于单个建模类别,“报告”发生的比例范围为0.31%,95%置信区间(CI)[0.23, 0.41]至0.77,95% CI:[0.68, 0.86]。一个类别是否被认为是“可重复”的比例范围为0.22,95% CI:[0.15, 0.31]至0.44,95% CI:[0.35, 0.55]。相对较低的比例强调了改善膝关节模型研究报告和可重复性的机会。正在进行的努力,包括我们的发现,有助于促进采用既提供可信度又提供翻译可能性的实践。
Reproducible research serves as a pillar of the scientific method and is a foundation for scientific advancement. However, estimates for irreproducibility of preclinical science range from 75% to 90%. The importance of reproducible science has not been assessed in the context of mechanics‐based modeling of human joints such as the knee, despite this being an area that has seen dramatic growth. Framed in the context of five experienced teams currently documenting knee modeling procedures, the aim of this study was to evaluate reporting and the perceived potential for reproducibility across studies the teams viewed as important contributions to the literature. A cohort of studies was selected by polling, which resulted in an assessment of nine studies as opposed to a broader analysis across the literature. Using a published checklist for reporting of modeling features, the cohort was evaluated for both “reporting” and their potential to be “reproduced,” which was delineated into six major modeling categories and three subcategories. Logistic regression analysis revealed that for individual modeling categories, the proportion of “reported” occurrences ranged from 0.31, 95% confidence interval (CI) [0.23, 0.41] to 0.77, 95% CI: [0.68, 0.86]. The proportion of whether a category was perceived as “reproducible” ranged from 0.22, 95% CI: [0.15, 0.31] to 0.44, 95% CI: [0.35, 0.55]. The relatively low ratios highlight an opportunity to improve reporting and reproducibility of knee modeling studies. Ongoing efforts, including our findings, contribute to a dialogue that facilitates adoption of practices that provide both credibility and translation possibilities.
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