Endosomal receptor trafficking: Retromer and beyond.
Endosomal receptor trafficking: Retromer and beyond.
复制标题
内体受体运输：Retromer 及其他
DOI：
10.1111/tra.12574
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Billadeau DD
中科院分区：
文献类型：
--
作者：
Wang J;Fedoseienko A;Chen B;Burstein E;Jia D;Billadeau DD
管状内溶酶体网络是一个质量控制系统，它确保内化受体正确递送至特定的亚细胞目的地，以维持细胞内稳态。尽管逆转运复合体最初在酵母中被描述为内体到高尔基体受体循环的调节因子，但哺乳动物的逆转运复合体已成为多种受体从内体到质膜循环的核心参与者。在过去的十年中，有关逆转运复合体促进受体运输的机制的信息已经出现，同时也鉴定出了许多与逆转运复合体相关的分子，包括WASH复合物、分选连接蛋白和TBC1d5。此外，最近的研究表明，几种分选连接蛋白可以直接与逆转运复合体的货物相互作用，以促进内体到高尔基体的回收，这为这些受体在细胞内的运输方式提供了新的见解。分选连接蛋白17的货物从内体系统循环出来的机制被证明涉及一种称为回收体的逆转运复合体样复合物，它通过与COMMD/CCDC22/CCDC93（CCC）复合物相互作用而被招募到WASH阳性内体。最后，细菌和病毒病原体劫持这种复杂的分选机制以逃避内溶酶体系统或隐藏在细胞内的机制开始显现。在这篇综述中，我们将重点介绍最近的一些研究，这些研究已经开始揭示逆转运复合体及其相关分子对受体运输的复杂作用，以及在这个分选区域的失调如何导致疾病或促进病原体感染。
The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations in order to maintain cellular homeostasis. Although retromer was originally described in yeast as a regulator of endosome‐to‐Golgi receptor recycling, mammalian retromer has emerged as a central player in endosome‐to‐plasma membrane recycling of a variety of receptors. Over the past decade, information regarding the mechanism by which retromer facilitates receptor trafficking has emerged, as has the identification of numerous retromer‐associated molecules including the WASH complex, sorting nexins (SNXs) and TBC1d5. Moreover, the recent demonstration that several SNXs can directly interact with retromer cargo to facilitate endosome‐to‐Golgi retrieval has provided new insight into how these receptors are trafficked in cells. The mechanism by which SNX17 cargoes are recycled out of the endosomal system was demonstrated to involve a retromer‐like complex termed the retriever, which is recruited to WASH positive endosomes through an interaction with the COMMD/CCDC22/CCDC93 (CCC) complex. Lastly, the mechanisms by which bacterial and viral pathogens highjack this complex sorting machinery in order to escape the endolysosomal system or remain hidden within the cells are beginning to emerge. In this review, we will highlight recent studies that have begun to unravel the intricacies by which the retromer and associated molecules contribute to receptor trafficking and how deregulation at this sorting domain can contribute to disease or facilitate pathogen infection.
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肌动蛋白调节波复合物的结构和控制。
影响因子：
64.8
作者：
Chen, Zhucheng;Borek, Dominika;Padrick, Shae B.;Gomez, Timothy S.;Metlagel, Zoltan;Ismail, Ayman M.;Umetani, Junko;Billadeau, Daniel D.;Otwinowski, Zbyszek;Rosen, Michael K.
通讯作者：
Rosen, Michael K.
影响因子：
39.3
作者：
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通讯作者：
Luo ZQ
影响因子：
21.3
作者：
Boettcher, Ralph Thomas;Stremmel, Christopher;Faessler, Reinhard
通讯作者：
Faessler, Reinhard
影响因子：
4
作者：
Balderhaar, Henning J. Kleine;Arlt, Henning;Ungermann, Christian
通讯作者：
Ungermann, Christian
DOI：
10.1073/pnas.1410552111
发表时间：
2014-09-02
影响因子：
11.1
作者：
Gallon, Matthew;Clairfeuille, Thomas;Cullen, Peter J.
通讯作者：
Cullen, Peter J.