New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation
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对 LINE-1 逆转录转座在人类疾病和免疫调节中相关作用的新认识
DOI：
10.3389/fcell.2020.00657
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发表时间：
2020-08
影响因子：
5.5
通讯作者：
Yu Jinpu
中科院分区：
文献类型：
--
作者：
Zhang Xiao;Zhang Rui;Yu Jinpu
长散在核元件-1（LINE-1）逆转录转座是癌症的主要标志，伴随着全局染色体不稳定性、基因组不稳定性和遗传异质性，并且已经成为许多疾病的发生、发展和不良预后的一个指标。LINE-1还调节免疫系统，并以多种方式影响免疫微环境。LINE-1逆转录转座子的异常表达可以为先天免疫反应提供强刺激，激活免疫系统，并诱导自身免疫和炎症。因此，抑制LINE-1的活性已成为各种疾病的潜在治疗策略。本文综述了LINE-1的组成成分、调控机制、与疾病和免疫的关系以及LINE-1的多种抑制剂，为LINE-1的研究提供了新的认识。
Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of cancer accompanied by global chromosomal instability, genomic instability, and genetic heterogeneity and has become one indicator for the occurrence, development, and poor prognosis of many diseases. LINE-1 also modulates the immune system and affects the immune microenvironment in a variety of ways. Aberrant expression of LINE-1 retrotransposon can provide strong stimuli for an innate immune response, activate the immune system, and induce autoimmunity and inflammation. Therefore, inhibition the activity of LINE-1 has become a potential treatment strategy for various diseases. In this review, we discussed the components and regulatory mechanisms involved with LINE-1, its correlations with disease and immunity, and multiple inhibitors of LINE-1, providing a new understanding of LINE-1.
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