Sex differences in circuits activated by corticotropin releasing factor in rats.
Sex differences in circuits activated by corticotropin releasing factor in rats.
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DOI：
10.1016/j.yhbeh.2017.10.004
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发表时间：
2018-01
影响因子：
3.5
通讯作者：
Bangasser DA
中科院分区：
文献类型：
--
作者：
Salvatore M;Wiersielis KR;Luz S;Waxler DE;Bhatnagar S;Bangasser DA
Women are more likely than men to suffer from psychiatric disorders characterized by corticotropin releasing factor (CRF) hypersecretion, suggesting sex differences in CRF sensitivity. In rodents, sex differences in the sensitivity of specific brain regions to CRF have been identified. However, regions do not work in isolation, but rather form circuits to coordinate distinct responses to stress. Here we examined whether CRF activates different circuits in male and female rats. Following central administration of CRF or artificial cerebrospinal fluid (aCSF), neuronal activation in stress-related areas was assessed using cFOS. Functional connectivity was gauged by correlating cFOS-positive cells between regions and then identifying differences in correlations for aCSF-treated and CRF-treated groups within sex. This analysis revealed that CRF altered different circuits in males and females. As an example, CRF altered correlations involving the dorsal raphe in males and the bed nucleus of the stria terminalis in females, suggesting sex differences in stress-activated circuits controlling mood and anxiety. Next, plasma estradiol and progesterone levels were correlated with cFOS counts in females. Negative correlations between estradiol and neuronal activation in the regions within the extended amygdala were found in CRF-treated, but not aCSF-treated females. This result suggests that estrogens and CRF interact to modulate the fear and anxiety responses mediated by these regions. Collectively, these studies reveal sex differences in the way brain regions work together in response to CRF. These differences could drive different stress coping strategies in males and females, perhaps contributing to sex biases in psychopathology.
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