Sex differences in stress-related psychiatric disorders: neurobiological perspectives.
Sex differences in stress-related psychiatric disorders: neurobiological perspectives.
复制标题
与压力有关的精神疾病的性别差异：神经生物学观点。
DOI：
10.1016/j.yfrne.2014.03.008
复制
发表时间：
2014-08
影响因子：
7.4
通讯作者：
Valentino, Rita J.
中科院分区：
文献类型：
--
作者：
Bangasser, Debra A.;Valentino, Rita J.
关键词：
压力与几种精神疾病的发作和严重程度有关，这些精神疾病在女性中比男性更常见，包括创伤后应激障碍（PTSD）和抑郁症。患有这些疾病的患者表现出几种应激反应系统的失调，包括对应激的神经内分泌反应、对负价刺激的皮质边缘反应和过度觉醒。因此，其潜在电路中的性别差异可以解释疾病患病率的性别偏见。这篇综述介绍了临床研究，确定这些电路的活动中的性别差异，以及临床前研究，证明细胞和分子的性别差异，在应激反应系统。这些研究揭示了从分子到系统水平的性别差异，这些差异增加了女性对压力的内分泌，情绪和唤醒反应。探索这些性别差异是至关重要的，因为这项研究可以揭示易受压力相关精神疾病影响的神经生物学基础，并指导新药物治疗的开发。
Stress is associated with the onset and severity of several psychiatric disorders that occur more frequently in women than men, including posttraumatic stress disorder (PTSD) and depression. Patients with these disorders present with dysregulation of several stress response systems, including the neuroendocrine response to stress, corticolimbic responses to negatively valenced stimuli, and hyperarousal. Thus, sex differences within their underlying circuitry may explain sex biases in disease prevalence. This review describes clinical studies that identify sex differences within the activity of these circuits, as well as preclinical studies that demonstrate cellular and molecular sex differences in stress responses systems. These studies reveal sex differences from the molecular to the systems level that increase endocrine, emotional, and arousal responses to stress in females. Exploring these sex differences is critical because this research can reveal the neurobiological underpinnings of vulnerability to stress-related psychiatric disorders and guide the development of novel pharmacotherapies.
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