Estrogen receptor expression and increased risk of lymphovascular space invasion in high-grade serous ovarian carcinoma.
Estrogen receptor expression and increased risk of lymphovascular space invasion in high-grade serous ovarian carcinoma.
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DOI：
10.1016/j.ygyno.2014.03.563
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发表时间：
2014-06
影响因子：
4.7
通讯作者：
Sood AK
中科院分区：
文献类型：
--
作者：
Matsuo K;Sheridan TB;Mabuchi S;Yoshino K;Hasegawa K;Studeman KD;Im DD;Rosenshein NB;Roman LD;Sood AK
最近的研究表明，淋巴管间隙侵犯（LVSI）与卵巢上皮性癌患者的血行和淋巴转移风险增加以及临床预后不良相关。考虑到雌激素在促进卵巢癌转移中的作用，我们研究了雌激素受体与高级别浆液性卵巢癌LVSI之间的潜在联系。对121例I ~ IV期高级别浆液性卵巢癌患者行原发性肿瘤细胞减灭术，检测ER、PR、p53、MDR 1、EGFR、HER 2、DNA倍体和S期细胞比例。生物标志物表达与LVSI和生存结局相关。101例（83.5%）观察到LVSI。检测的生物标志物的免疫组织化学显示ER（86.7%）是最常表达的，其次是p53（71.4%）、HER 2（68.3%）、EGFR（52.1%）、MDR-1（14.3%）和PR（8.9%）。ER表达与PR表达正相关（r=0.31，p=0.001）。LVSI仅与ER相关（优势比6.27，95%CI 1.93-20.4，p=0.002），而与其他生物标志物无关。在多变量分析中，ER与LVSI显著相关（p=0.039）。LVSI仍然是无进展生存期（HR 3.01，95%CI 1.54-5.88，p=0.001）和总生存期（HR 2.69，95%CI 1.18-6.23，p=0.021）降低的重要预后因素，而ER表达在多变量分析中不再是重要变量。我们的数据表明雌激素受体与LVSI呈正相关，LVSI是高级别浆液性卵巢癌预后不良的独立预后指标。本研究强调雌激素通路在促进高级别浆液性卵巢癌淋巴管或血管扩散中的重要性。
Recent studies have demonstrated that lymphovascular space invasion (LVSI) is associated with increased risk of hematogenous and lymphatic metastasis and poor clinical outcome of women with epithelial ovarian cancer. Given the suspected role of estrogen in promoting ovarian cancer metastasis, we examined potential links between estrogen receptor and LVSI in high-grade serous ovarian carcinoma. Tumoral expression of ER, PR, p53, MDR1, EGFR, HER2, DNA ploidy, and S-phase fraction was examined for 121 cases of stage I-IV high-grade serous ovarian carcinoma samples obtained at primary cytoreductive surgery. Biomarker expression was correlated to LVSI and survival outcomes. LVSI was observed in 101 (83.5%) of all cases. Immunohistochemistry of tested biomarkers showed ER (86.7%) to be the most commonly expressed followed by p53 (71.4%), HER2 (68.3%), EGFR (52.1%), MDR-1 (14.3%), and PR (8.9%). ER expression was positively correlated to PR expression (r=0.31, p=0.001). LVSI was only correlated with ER (odds ratio 6.27, 95%CI 1.93-20.4, p=0.002) but not with other biomarkers. In multivariate analysis, ER remained significantly associated with LVSI (p=0.039). LVSI remained a significant prognostic factor for decreased progression-free survival (HR 3.01, 95%CI 1.54-5.88, p=0.001) and overall survival (HR 2.69, 95%CI 1.18-6.23, p=0.021) while ER-expression did not remain as a significant variable in multivariate analysis. Our data demonstrated that estrogen receptor was positively correlated with LVSI that was an independent prognostic indicator of poor survival outcomes of high-grade serous ovarian carcinoma. This study emphasizes the importance of estrogen pathway in promoting lymphatic or vascular spread of high-grade serous ovarian carcinoma.
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DOI：
10.1016/j.jtcvs.2006.10.019
发表时间：
2007-02-01
影响因子：
6
作者：
d'Amato, Thomas A.;Landreneau, Rodney J.;Luketich, James D.
通讯作者：
Luketich, James D.
影响因子：
4.7
作者：
Risch, HA
通讯作者：
Risch, HA
影响因子：
3.8
作者：
Poola I;Yue Q
通讯作者：
Yue Q
影响因子：
158.5
作者：
Burger, Robert A.;Brady, Mark F.;Liang, Sharon X.
通讯作者：
Liang, Sharon X.
影响因子：
254.7
作者：
Siegel, Rebecca;Naishadham, Deepa;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin