Monocyte subpopulations as important biomarkers of resistence and susceptibility during experimental infection with Leishmania (Leishmania) major.
Monocyte subpopulations as important biomarkers of resistence and susceptibility during experimental infection with Leishmania (Leishmania) major.
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DOI：
10.1016/j.biopha.2018.08.154
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Gonçalves R
中科院分区：
文献类型：
--
作者：
Martins TAF;Barbosa VS;Almeida GG;Antonelli LRDV;Tafuri WL;Mosser DM;Gonçalves R
内脏利什曼病是一种慢性、致命性寄生虫病。在感染的后期，可以观察到血液病的表现，包括某些白细胞的频率和表型的改变。缺乏良好的预后指标来表征患者正在进行的临床状态。在这项研究中，我们分析了感染大利什曼原虫的小鼠单核细胞亚群的频率。我们的结果表明，在BALB/c和感染主要乳杆菌的C57BL/6小鼠中，单核细胞频率的增加与病变的发展显著相关。在BALB/c小鼠中，我们观察到GR1+单核细胞的频率与病变大小之间存在显着的相关性。此外，用Anfotericin B治疗感染的BALB/c小鼠以解决病变，与未治疗的感染BALB/c小鼠相比，导致GR1+单核细胞的频率降低。C57BL/6感染的小鼠通常能解决感染，但在感染的愈合阶段，单核细胞数量会减少。结果表明，通过分析单核细胞频率可以预测疾病的严重程度。因此，我们认为单核细胞的频率可以用来定义疾病的严重程度以及实验性利什曼病治疗的成功。
Visceral Leishmaniasis is a chronic and lethal, parasitic disease. In the later infection stages, it is known that expressive hematological disorders can be observed, including changes in the frequency and phenotype of certain leukocytes. There is a lack of good prognostic indicators to characterize the on-goin clinical status of the patient. In this study, we have analyzed the frequency of monocyte subpopulations in mice infected with Leishmania major (L. major). Our results show a significant correlation between increased blood monocyte frequency and lesion development in both BALB/c and in the C57BL/6 mice infected with L. major. In BALB/c mice we observed a significant correlation between the frequency of GR1+ monocytes and lesion size. Furthermore, treatment of infected BALB/c mice with Anfotericin B, to resolve lesions, resulted in a lower frequency of GR1+ monocytes compared to untreated infected BALB/c mice. C57BL/6 infected mice, which normally resolve infections, show decreased numbers of monocytes during the healing phase of infection. The results indicate that disease severity can be predicted by analyzing monocyte frequency. Thus, we propose that the frequency of monocytes, can be used to define the severity of the disease as well as the success of the treatment in experimental leishmaniasis.
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重组白介素12治愈感染了利什曼原虫大调的小鼠。
影响因子：
15.3
作者：
Heinzel, F P;Schoenhaut, D S;Rerko, R M;Rosser, L E;Gately, M K
通讯作者：
Gately, M K
DOI：
10.1084/jem.169.1.59
发表时间：
1989-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Heinzel FP;Sadick MD;Holaday BJ;Coffman RL;Locksley RM
通讯作者：
Locksley RM
影响因子：
3.1
作者：
Conrad, Sean M.;Strauss-Ayali, Dalit;Mosser, David M.
通讯作者：
Mosser, David M.
影响因子：
2.7
作者：
SHAPIRO, SS;WILK, MB
通讯作者：
WILK, MB
影响因子：
4.3
作者：
Mitchell, Andrew J.;Roediger, Ben;Weninger, Wolfgang
通讯作者：
Weninger, Wolfgang